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Science 8 December 1989:
Vol. 246. no. 4935, pp. 1298 - 1300
DOI: 10.1126/science.2573953
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Articles

Science, Vol 246, Issue 4935, 1298-1300
Copyright © 1989 by American Association for the Advancement of Science

articles

A new DNA marker tightly linked to the fragile X locus (FRAXA)

GK Suthers, DF Callen, VJ Hyland, HM Kozman, E Baker, H Eyre, PS Harper, SH Roberts, MC Hors-Cayla, KE Davies, and al. et

Department of Histopathology, Adelaide Children's Hospital, Australia.

The fragile X syndrome is the most common cause of familial mental retardation. Genetic counseling and gene isolation are hampered by a lack of DNA markers close to the disease locus. Two somatic cell hybrids that each contain a human X chromosome with a breakpoint close to the fragile X locus have been characterized. A new DNA marker (DXS296) lies between the chromosome breakpoints and is the closest marker to the fragile X locus yet reported. The Hunter syndrome gene, which causes iduronate sulfatase deficiency, is located at the X chromosome breakpoint that is distal to this new marker, thus localizing the Hunter gene distal to the fragile X locus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Direct DNA Testing for Fragile X Syndrome.
F. J. Ramos, D. L. Eunpu, B. Finucane, and E. G. Pfendner (1993)
Arch Pediatr Adolesc Med 147, 1231-1235
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