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Science 3 November 1989:
Vol. 246. no. 4930, pp. 658 - 661
DOI: 10.1126/science.2554495
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Articles

Science, Vol 246, Issue 4930, 658-661
Copyright © 1989 by American Association for the Advancement of Science

articles

A liver-specific enhancer in the core promoter region of human hepatitis B virus

JK Yee

Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla 92093.

An 88-base pair fragment in the core promoter of the human hepatitis B virus (HBV) contains a functional promoter and a strong liver-specific enhancer. This enhancer functions in human hepatoma cells, where it is much more active than the previously described HBV enhancer in stimulating expression of the linked bacterial chloramphenicol acetyltransferase gene expressed from heterologous promoters. Studies of the role of this enhancer-promoter in HBV may help to clarify mechanisms of gene expression in cells infected with HBV and the role of the virus in the pathogenesis of hepatitis and hepatocellular carcinoma.


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Purification and Properties of Rat Liver Nuclear Proteins That Interact with the Hepatitis B Virus Enhancer 1.
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