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Science 27 October 1989:
Vol. 246. no. 4929, pp. 494 - 497
DOI: 10.1126/science.2683072
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Articles

Science, Vol 246, Issue 4929, 494-497
Copyright © 1989 by American Association for the Advancement of Science

articles

Normal expression of a rearranged and mutated c-myc oncogene after transfection into fibroblasts

A Richman and A Hayday

Biology Department, Yale University, New Haven, CT 06511.

Expression of the c-myc oncogene is deregulated in a variety of malignancies. Rearrangement and mutation of the c-myc locus is a characteristic feature of human Burkitt's lymphoma. Whether deregulation is solely a result of mutation of c-myc or whether it is influenced by the transformed B cell context has not been determined. A translocated and mutated allele of c-myc was stably transfected into fibroblasts. The rearranged allele was expressed indistinguishably from a normal c-myc gene: it had serum-regulated expression, was transcribed with normal promoter preference, and was strongly attenuated. Thus mutations by themselves are insufficient to deregulate c-myc transcription.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cutting Edge: The Expression In Vivo of a Second Isoform of pT{alpha}: Implications for the Mechanism of pT{alpha} Action.
D. F. Barber, L. Passoni, L. Wen, L. Geng, and A. C. Hayday (1998)
J. Immunol. 161, 11-16
   Abstract »    Full Text »    PDF »
Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells..
L Madisen and M Groudine (1994)
Genes & Dev. 8, 2212-2226
   Abstract »    PDF »


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