Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 20 October 1989:
Vol. 246. no. 4928, pp. 385 - 388
DOI: 10.1126/science.2799392
Prev | Table of Contents | Next

Articles

Science, Vol 246, Issue 4928, 385-388
Copyright © 1989 by American Association for the Advancement of Science

articles

The neostriatal mosaic: striatal patch-matrix organization is related to cortical lamination

CR Gerfen

Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892.

The basal ganglia, of which the striatum is the major component, process inputs from virtually all cerebral cortical areas to affect motor, emotional, and cognitive behaviors. Insights into how these seemingly disparate functions may be integrated have emerged from studies that have demonstrated that the mammalian striatum is composed of two compartments arranged as a mosaic, the patches and the matrix, which differ in their neurochemical and neuroanatomical properties. In this study, projections from prefrontal, cingulate, and motor cortical areas to the striatal compartments were examined with the Phaseolus vulgaris-leucoagglutinin (PHA-L) anterograde axonal tracer in rats. Each cortical area projects to both the patches and the matrix of the striatum; however, deep layer V and layer VI corticostriatal neurons project principally to the patches, whereas superficial layer V and layer III and II corticostriatal neurons project principally to the matrix. The relative contribution of patch and matrix corticostriatal projections varies among the cortical areas examined such that allocortical areas provide a greater number of inputs to the patches than to the matrix, whereas the reverse obtains for neocortical areas. These results demonstrate that the compartmental organization of corticostriatal inputs is related to their laminar origin and secondarily to the cytoarchitectonic area of origin.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Single Nigrostriatal Dopaminergic Neurons Form Widely Spread and Highly Dense Axonal Arborizations in the Neostriatum.
W. Matsuda, T. Furuta, K. C. Nakamura, H. Hioki, F. Fujiyama, R. Arai, and T. Kaneko (2009)
J. Neurosci. 29, 444-453
   Abstract »    Full Text »    PDF »
SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons.
K. Y. Kwan, M. M. S. Lam, Z. Krsnik, Y. I. Kawasawa, V. Lefebvre, and N. Sestan (2008)
PNAS 105, 16021-16026
   Abstract »    Full Text »    PDF »
Temporal regulation of ephrin/Eph signalling is required for the spatial patterning of the mammalian striatum.
L. Passante, N. Gaspard, M. Degraeve, J. Frisen, K. Kullander, V. De Maertelaer, and P. Vanderhaeghen (2008)
Development 135, 3281-3290
   Abstract »    Full Text »    PDF »
Corticostriatal and Thalamostriatal Synapses Have Distinctive Properties.
J. Ding, J. D. Peterson, and D. J. Surmeier (2008)
J. Neurosci. 28, 6483-6492
   Abstract »    Full Text »    PDF »
Dynamic Changes in Vesicular Glutamate Transporter 1 Function and Expression Related to Methamphetamine-Induced Glutamate Release.
K. A. Mark, M. S. Quinton, S. J. Russek, and B. K. Yamamoto (2007)
J. Neurosci. 27, 6823-6831
   Abstract »    Full Text »    PDF »
Recurrent connection patterns of corticostriatal pyramidal cells in frontal cortex..
M. Morishima and Y. Kawaguchi (2006)
J. Neurosci. 26, 4394-4405
   Abstract »    Full Text »    PDF »
The striatofugal fiber system in primates: A reevaluation of its organization based on single-axon tracing studies.
M. Levesque and A. Parent (2005)
PNAS 102, 11888-11893
   Abstract »    Full Text »    PDF »
High-Dose Methamphetamine Acutely Activates the Striatonigral Pathway to Increase Striatal Glutamate and Mediate Long-Term Dopamine Toxicity.
K. A. Mark, J.-J. Soghomonian, and B. K. Yamamoto (2004)
J. Neurosci. 24, 11449-11456
   Abstract »    Full Text »    PDF »
Neuronal Activity in the Rodent Dorsal Striatum in Sequential Navigation: Separation of Spatial and Reward Responses on the Multiple T Task.
N. Schmitzer-Torbert and A. D. Redish (2004)
J Neurophysiol 91, 2259-2272
   Abstract »    Full Text »    PDF »
Efficacy of Rehabilitative Experience Declines with Time after Focal Ischemic Brain Injury.
J. Biernaskie, G. Chernenko, and D. Corbett (2004)
J. Neurosci. 24, 1245-1254
   Abstract »    Full Text »    PDF »
Synaptic Convergence of Motor and Somatosensory Cortical Afferents onto GABAergic Interneurons in the Rat Striatum.
S. Ramanathan, J. J. Hanley, J.-M. Deniau, and J. P. Bolam (2002)
J. Neurosci. 22, 8158-8169
   Abstract »    Full Text »    PDF »
Corticostriatal Combinatorics: The Implications of Corticostriatal Axonal Arborizations.
T. Zheng and C. J. Wilson (2002)
J Neurophysiol 87, 1007-1017
   Abstract »    Full Text »    PDF »
Differential Metabolic Activity in the Striosome and Matrix Compartments of the Rat Striatum during Natural Behaviors.
L. L. Brown, S. M. Feldman, D. M. Smith, J. R. Cavanaugh, R. F. Ackermann, and A. M. Graybiel (2002)
J. Neurosci. 22, 305-314
   Abstract »    Full Text »    PDF »
Preferential Cytoplasmic Localization of {delta}-Opioid Receptors in Rat Striatal Patches: Comparison with Plasmalemmal {micro}-Opioid Receptors.
H. Wang and V. M. Pickel (2001)
J. Neurosci. 21, 3242-3250
   Abstract »    Full Text »    PDF »
Three-Dimensional Topography of Corticopontine Projections from Rat Barrel Cortex: Correlations with Corticostriatal Organization.
T. B. Leergaard, K. D. Alloway, J. J. Mutic, and J. G. Bjaalie (2000)
J. Neurosci. 20, 8474-8484
   Abstract »    Full Text »    PDF »
Serotonin Induces EPSCs Preferentially in Layer V Pyramidal Neurons of the Frontal Cortex in the Rat.
E.K. Lambe, P.S. Goldman-Rakic, and G.K. Aghajanian (2000)
Cereb Cortex 10, 974-980
   Abstract »    Full Text »    PDF »
Age-Related Cognitive Deficits Mediated by Changes in the Striatal Dopamine System.
L. Bäckman, N. Ginovart, R. A. Dixon, T.-B. R. Wahlin, Åk. Wahlin, C. Halldin, and L. Farde (2000)
Am J Psychiatry 157, 635-637
   Abstract »    Full Text »
Ephrin-A Binding and EphA Receptor Expression Delineate the Matrix Compartment of the Striatum.
L. S. Janis, R. M. Cassidy, and L. F. Kromer (1999)
J. Neurosci. 19, 4962-4971
   Abstract »    Full Text »    PDF »
Anesthetics Eliminate Somatosensory-Evoked Discharges of Neurons in the Somatotopically Organized Sensorimotor Striatum of the Rat.
M. O. West (1998)
J. Neurosci. 18, 9055-9068
   Abstract »    Full Text »    PDF »
Preferential localization of self-stimulation sites in striosomes/patches in the rat striatum.
N. M. White and N. Hiroi (1998)
PNAS 95, 6486-6491
   Abstract »    Full Text »    PDF »
Different Patterns of Neuronal Infection after Intracerebral Injection of Two Strains of Pseudorabies Virus.
J. P. Card, P. Levitt, and L. W. Enquist (1998)
J. Virol. 72, 4434-4441
   Abstract »    Full Text »    PDF »
The anatomical relationships of the prefrontal cortex with limbic structures and the basal ganglia.
H. J. Groenewegen, C. I. Wright, and H. B. M. Uylings (1997)
J Psychopharmacol 11, 99-106
   Abstract »    PDF »
Frontal-subcortical circuits: the anatomic basis of executive, social and motivated behaviors.
D. L. Masterman and J. L. Cummings (1997)
J Psychopharmacol 11, 107-114
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)