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Science 13 October 1989:
Vol. 246. no. 4927, pp. 255 - 257
DOI: 10.1126/science.2799387
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Articles

Science, Vol 246, Issue 4927, 255-257
Copyright © 1989 by American Association for the Advancement of Science

articles

Electrophysiologic responses in hamster superior colliculus evoked by regenerating retinal axons

SA Keirstead, M Rasminsky, Y Fukuda, DA Carter, AJ Aguayo, and M Vidal-Sanz

Neurosciences Unit, Montreal General Hospital, Quebec, Canada.

Autologous peripheral nerve grafts were used to permit and direct the regrowth of retinal ganglion cell axons from the eye to the ipsilateral superior colliculus of adult hamsters in which the optic nerves had been transected within the orbit. Extracellular recordings in the superior colliculus 15 to 18 weeks after graft insertion revealed excitatory and inhibitory postsynaptic responses to visual stimulation. The finding of light-induced responses in neurons in the superficial layers of the superior colliculus close to the graft indicates that axons regenerating from axotomized retinal ganglion cells can establish electrophysiologically functional synapses with neurons in the superior colliculus of these adult mammals.


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