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Science 13 October 1989:
Vol. 246. no. 4927, pp. 251 - 255
DOI: 10.1126/science.2799386
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Articles

Science, Vol 246, Issue 4927, 251-255
Copyright © 1989 by American Association for the Advancement of Science

articles

Human genotoxicity: pesticide applicators and phosphine

VF Garry, J Griffith, TJ Danzl, RL Nelson, EB Whorton, LA Krueger, and J Cervenka

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55414.

Fumigant applicators who, 6 weeks to 3 months earlier, were exposed to phosphine, a common grain fumigant, or to phosphine and other pesticides had significantly increased stable chromosome rearrangements, primarily translocations in G-banded lymphocytes. Less stable aberrations including chromatid deletions and gaps were significantly increased only during the application season, but not at this later time point. During fumigant application, measured exposure to phosphine exceeds accepted national standards. Because phosphine is also used as a dopant in the microchip industry and is generated in waste treatment, the possibility of more widespread exposure and long-term health sequelae must be considered.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The rate-limiting step in anaerobic digestion in the presence of phosphine.
Q. Mahmood, Z. Ping, G. X. Li, and L. L. Mei (2006)
Toxicology and Industrial Health 22, 165-172
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GRAIN FUMIGATION HAS POSSIBLE GENOTOXIC EFFECTS.
(1989)
Journal Watch (General) 1989, 7
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Room at the top.
J Palca (1989)
Science 246, 566-568
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