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Science 22 September 1989:
Vol. 245. no. 4924, pp. 1385 - 1387
DOI: 10.1126/science.2551038
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Articles

Science, Vol 245, Issue 4924, 1385-1387
Copyright © 1989 by American Association for the Advancement of Science

articles

Long-term potentiation in the motor cortex

A Iriki, C Pavlides, A Keller, and H Asanuma

Rockefeller University, New York, NY 10021.

Long-term potentiation (LTP) is a model for learning and memory processes. Tetanic stimulation of the sensory cortex produces LTP in motor cortical neurons, whereas tetanization of the ventrolateral nucleus of the thalamus, which also projects to the motor cortex, does not. However, after simultaneous high-frequency stimulation of both the sensory cortex and the ventrolateral nucleus of the thalamus, LTP of thalamic input to motor cortical neurons is induced. This associative LTP occurs only in neurons in the superficial layers of the motor cortex that receive monosynaptic input from both the sensory cortex and the ventrolateral nucleus of the thalamus. Associative LTP in the motor cortex may constitute a basis for the retention of motor skills.


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