Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 September 1989:
Vol. 245. no. 4923, pp. 1249 - 1251
DOI: 10.1126/science.2476848
Prev | Table of Contents | Next

Articles

Science, Vol 245, Issue 4923, 1249-1251
Copyright © 1989 by American Association for the Advancement of Science

articles

Acetylcholine and GABA mediate opposing actions on neuronal chloride channels in crayfish

C Pfeiffer-Linn and RM Glantz

Department of Biology, Rice University, Houston TX 77251.

A central principle of neural integration is that excitatory and inhibitory neurotransmitters effect the opening of distinct classes of membrane ionic channels and that integration consists of the summation of the opposing ionic currents on the postsynaptic membrane. In tangential cells of crayfish optic lobes, a hyperpolarizing, biphasic synaptic potential is produced by the concurrent action of acetylcholine and gamma aminobutyric acid (GABA). Acetylcholine hyperpolarizes the cell and increases chlorine conductance. GABA depolarizes the cell by closing some of the same chloride channels. Therefore, in this case integration is achieved by the antagonistic actions of two transmitters on the same ionic channel.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Coordinated Excitatory Effect of GABAergic Interneurons on Three Feeding Motor Programs in the Mollusk Clione limacina.
T. P. Norekian and A. Y. Malyshev (2005)
J Neurophysiol 93, 305-315
   Abstract »    Full Text »    PDF »
Expression and Functional Characterization of GABA Transporters in Crayfish Neurosecretory Cells.
J. Garduno, S. Elenes, J. Cebada, E. Becerra, and U. Garcia (2002)
J. Neurosci. 22, 9176-9184
   Abstract »    Full Text »    PDF »
GABAergic Excitatory Synapses and Electrical Coupling Sustain Prolonged Discharges in the Prey Capture Neural Network of Clione limacina.
T. P. Norekian (1999)
J. Neurosci. 19, 1863-1875
   Abstract »    Full Text »    PDF »
Mapping Membrane Potential Transients in Crayfish (Procambarus clarkii) Optic Lobe Neuropils With Voltage-Sensitive Dyes.
S. Yagodin, C. Collin, D. L. Alkon, N. F. Sheppard Jr., and D. B. Sattelle (1999)
J Neurophysiol 81, 334-344
   Abstract »    Full Text »    PDF »
Directionality and Inhibition in Crayfish Tangential Cells.
R. M. Glantz (1998)
J Neurophysiol 79, 1157-1166
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)