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Science 25 August 1989:
Vol. 245. no. 4920, pp. 862 - 866
DOI: 10.1126/science.2549638
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Articles

Science, Vol 245, Issue 4920, 862-866
Copyright © 1989 by American Association for the Advancement of Science

articles

Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP

R Malinow, H Schulman, and RW Tsien

Department of Molecular and Cellular Physiology, Beckman Center, Stanford University School of Medicine 94305.

Long-term potentiation (LTP) of synaptic transmission is a widely studied cellular example of synaptic plasticity. However, the identity, localization, and interplay among the biochemical signals underlying LTP remain unclear. Intracellular microelectrodes have been used to record synaptic potentials and deliver protein kinase inhibitors to postsynaptic CA1 pyramidal cells. Induction of LTP is blocked by intracellular delivery of H-7, a general protein kinase inhibitor, or PKC(19-31), a selective protein kinase C (PKC) inhibitor, or CaMKII(273-302), a selective inhibitor of the multifunctional Ca2+-calmodulin-dependent protein kinase (CaMKII). After its establishment, LTP appears unresponsive to postsynaptic H-7, although it remains sensitive to externally applied H-7. Thus both postsynaptic PKC and CaMKII are required for the induction of LTP and a presynaptic protein kinase appears to be necessary for the expression of LTP.


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   Abstract »    Full Text »    PDF »
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D.-J. Zou and H. T. Cline (1999)
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J Neurophysiol 80, 1623-1629
   Abstract »    Full Text »    PDF »
Requirement of rapid Ca2+ entry and synaptic activation of metabotropic glutamate receptors for the induction of long-term depression in adult rat hippocampus.
S. Otani and J. A Connor (1998)
J. Physiol. 511, 761-770
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Selective Abolition of the NMDA Component of Long-Term Potentiation in Mice Lacking mGluR5.
Z. Jia, Y. Lu, J. Henderson, F. Taverna, C. Romano, W. Abramow-Newerly, J. M. Wojtowicz, and J. Roder (1998)
Learn. Mem. 5, 331-343
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CA1 Long-Term Potentiation Is Diminished but Present in Hippocampal Slices from alpha -CaMKII Mutant Mice.
H. L. Hinds, S. Tonegawa, and R. Malinow (1998)
Learn. Mem. 5, 344-354
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Calcium-Evoked Dendritic Exocytosis in Cultured Hippocampal Neurons. Part II: Mediation by Calcium/Calmodulin-Dependent Protein Kinase II.
M. Maletic-Savatic, T. Koothan, and R. Malinow (1998)
J. Neurosci. 18, 6814-6821
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Phosphorylation at the Nuclear Localization Signal of Ca2+/Calmodulin-dependent Protein Kinase II Blocks Its Nuclear Targeting.
E. K. Heist, M. Srinivasan, and H. Schulman (1998)
J. Biol. Chem. 273, 19763-19771
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Adducin Is an In Vivo Substrate for Protein Kinase C: Phosphorylation in the MARCKS-related Domain Inhibits Activity in Promoting Spectrin-Actin Complexes and Occurs in Many Cells, Including Dendritic Spines of Neurons.
Y. Matsuoka, X. Li, and V. Bennett (1998)
J. Cell Biol. 142, 485-497
   Abstract »    Full Text »    PDF »
Cell-Permeable Scavengers of Superoxide Prevent Long-Term Potentiation in Hippocampal Area CA1.
E. Klann (1998)
J Neurophysiol 80, 452-457
   Abstract »    Full Text »    PDF »
Differential roles of Ca2+/calmodulin-dependent kinases in posttetanic potentiation at input selective glutamatergic pathways.
D. Wang and L. Maler (1998)
PNAS 95, 7133-7138
   Abstract »    Full Text »    PDF »
Downregulation of Transient K+ Channels in Dendrites of Hippocampal CA1 Pyramidal Neurons by Activation of PKA and PKC.
D. A. Hoffman and D. Johnston (1998)
J. Neurosci. 18, 3521-3528
   Abstract »    Full Text »    PDF »


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