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Science 28 July 1989:
Vol. 245. no. 4916, pp. 415 - 417
DOI: 10.1126/science.2569236
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Articles

Science, Vol 245, Issue 4916, 415-417
Copyright © 1989 by American Association for the Advancement of Science

articles

Brain region and gene specificity of neuropeptide gene expression in cultured astrocytes

H Shinoda, AM Marini, C Cosi, and JP Schwartz

Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.

Astrocytes have many neuronal characteristics, such as neurotransmitter receptors, ion channels, and neurotransmitter uptake systems. Cultured astrocytes were shown to express certain neuropeptide genes, with specificity for both the gene expressed and the brain region from which the cells were prepared. Somatostatin messenger RNA and peptides were detected only in cerebellar astrocytes, whereas proenkephalin messenger RNA and enkephalin peptides were present in astrocytes of cortex, cerebellum, and striatum. Cholecystokinin was not expressed in any of the cells. These results support the hypothesis that peptides synthesized in astrocytes may play a role in the development of the central nervous system.


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A Regulated Secretory Pathway in Cultured Hippocampal Astrocytes.
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Egr-1 Activates Basic Fibroblast Growth Factor Transcription. MECHANISTIC IMPLICATIONS FOR ASTROCYTE PROLIFERATION.
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