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Science 21 July 1989:
Vol. 245. no. 4915, pp. 269 - 276
DOI: 10.1126/science.2665079
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Articles

Science, Vol 245, Issue 4915, 269-276
Copyright © 1989 by American Association for the Advancement of Science

articles

The rat as an experimental animal

TJ Gill 3rd, GJ Smith, RW Wissler, and HW Kunz

University of Pittsburgh School of Medicine, PA 15261.

The development and characterization of many inbred, congenic, and recombinant strains of rats in recent years has led to the detailed genetic description of this species, especially in regard to its major histocompatibility complex. This information has contributed substantially to the study of comparative genetics and has greatly enhanced the utility of the rat in a variety of areas of biomedical research. This article focuses on the use of the rat in immunogenetics, transplantation, cancer-risk assessment, cardiovascular diseases, and behavior.


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