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Science 14 July 1989:
Vol. 245. no. 4914, pp. 186 - 188
DOI: 10.1126/science.2526370
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Articles

Science, Vol 245, Issue 4914, 186-188
Copyright © 1989 by American Association for the Advancement of Science

articles

Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury

JS Powell, JP Clozel, RK Muller, H Kuhn, F Hefti, M Hosang, and HR Baumgartner

Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd., Basel, Switzerland.

The role of a local angiotensin system in the vascular response to arterial injury was investigated by administering the angiotensin-converting enzyme (CE) inhibitor cilazapril to normotensive rats in which the left carotid artery was subjected to endothelial denudation and injury by balloon catheterization. In control animals, by 14 days after balloon injury, the processes of smooth muscle cell (SMC) proliferation, migration of SMCs from the media to the intima, and synthesis of extracellular matrix produced marked thickening of the intima, with reduction of the cross-sectional area of the lumen. However, in animals that received continuous treatment with the CE inhibitor, neointima formation was decreased (by about 80 percent), and lumen integrity was preserved. Thus, the angiotensin-converting enzyme may participate in modulating the proliferative response of the vascular wall after arterial injury, and inhibition of this enzyme may have therapeutic applications to prevent the proliferative lesions that occur after coronary angioplasty and vascular surgery.


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Y. Furukawa, A. Matsumori, N. Ohashi, T. Shioi, K. Ono, A. Harada, K. Matsushima, and S. Sasayama (1999)
Circ. Res. 84, 306-314
   Abstract »    Full Text »    PDF »
Vascular Injury Causes Neointimal Formation in Angiotensin II Type 1a Receptor Knockout Mice.
K. Harada, I. Komuro, T. Sugaya, K. Murakami, and Y. Yazaki (1999)
Circ. Res. 84, 179-185
   Abstract »    Full Text »    PDF »
Angiotensin II Type 1 Receptor Blockade Prevents Up-Regulation of Angiotensin II Type 1A Receptors in Rat Injured Artery.
S. Tazawa, T. Nakane, and S. Chiba (1999)
J. Pharmacol. Exp. Ther. 288, 898-904
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Strategies to achieve coronary arterial plaque stabilization.
R. Rabbani and E. J. Topol (1999)
Cardiovasc Res 41, 402-417
   Abstract »    Full Text »    PDF »
Prevention of Vascular Apoptosis in Myocardial Infarction by Losartan.
S. K. Sharma, D. Chapman, R. Temsah, T. Netticadan, D. P. Brasil, and N. S. Dhalla (1999)
Journal of Cardiovascular Pharmacology and Therapeutics 4, 77-84
   Abstract »    PDF »
Angiotensin-(1–7) Reduces Smooth Muscle Growth After Vascular Injury.
W. B. Strawn, C. M. Ferrario, and E. A. Tallant (1999)
Hypertension 33, 207-211
   Abstract »    Full Text »    PDF »
Angiotensin II Type 1 Receptor–Mediated Peroxide Production in Human Macrophages.
Y. Yanagitani, H. Rakugi, A. Okamura, K. Moriguchi, S. Takiuchi, M. Ohishi, K. Suzuki, J. Higaki, and T. Ogihara (1999)
Hypertension 33, 335-339
   Abstract »    Full Text »    PDF »
ACE Inhibitor Quinapril Reduces the Arterial Expression of NF-{kappa}B-Dependent Proinflammatory Factors but not of Collagen I in a Rabbit Model of Atherosclerosis.
M. A. Hernandez-Presa, C. Bustos, M. Ortego, J. Tunon, L. Ortega, and J. Egido (1998)
Am. J. Pathol. 153, 1825-1837
   Abstract »    Full Text »    PDF »
Induction of Angiotensin I-converting Enzyme Transcription by a Protein Kinase C-dependent Mechanism in Human Endothelial Cells.
E. Villard, A. Alonso, M. Agrapart, M. Challah, and F. Soubrier (1998)
J. Biol. Chem. 273, 25191-25197
   Abstract »    Full Text »    PDF »
Angiotensin-converting Enzyme Inhibition Delays Pulmonary Vascular Neointimal Formation.
K. OKADA, M. L. BERNSTEIN, W. ZHANG, D. P. SCHUSTER, and M. D. BOTNEY (1998)
Am. J. Respir. Crit. Care Med. 158, 939-950
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Increased Angiotensin II Type 1 Receptor Expression in Hypercholesterolemic Atherosclerosis in Rabbits.
B. C. Yang, M. I. Phillips, D. Mohuczy, H. Meng, L. Shen, P. Mehta, and J. L. Mehta (1998)
Arterioscler Thromb Vasc Biol 18, 1433-1439
   Abstract »    Full Text »    PDF »
Pathways for Angiotensin II Generation in Intact Human Tissue : Evidence From Comparative Pharmacological Interruption of the Renin System.
N. K. Hollenberg, N. D. L. Fisher, and D. A. Price (1998)
Hypertension 32, 387-392
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Negative Regulation of Local Hepatocyte Growth Factor Expression by Angiotensin II and Transforming Growth Factor-ß in Blood Vessels : Potential Role of HGF in Cardiovascular Disease.
N. Nakano, R. Morishita, A. Moriguchi, Y. Nakamura, S.-i. Hayashi, M. Aoki, I. Kida, K. Matsumoto, T. Nakamura, J. Higaki, et al. (1998)
Hypertension 32, 444-451
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Interaction of mRNAs for Angiotensin II Type 1 and Type 2 Receptors to Vascular Remodeling in Spontaneously Hypertensive Rats.
S. Otsuka, M. Sugano, N. Makino, S. Sawada, T. Hata, and Y. Niho (1998)
Hypertension 32, 467-472
   Abstract »    Full Text »    PDF »
Endovascular manipulation to restrict restenosis.
A. Gershlick (1998)
Vascular Medicine 3, 177-188
   Abstract »    PDF »
Differential action of angiotensin II and activity of angiotensin-converting enzyme in human bypass grafts.
J. A. Borland, A. H. Chester, S. Crabbe, J. B. Parkerson, J. D. Catravas, and M. H. Yacoub (1998)
J. Thorac. Cardiovasc. Surg. 116, 206-212
   Abstract »    Full Text »    PDF »
Eotaxin and Capping Protein in Experimental Vasculopathy.
J. Chen, L. M. Akyurek, B. Fellstrom, P. Hayry, and L. C. Paul (1998)
Am. J. Pathol. 153, 81-90
   Abstract »    Full Text »    PDF »
Why do animal models of post-angioplasty restenosis sometimes poorly predict the outcome of clinical trials?.
A. Lafont and D. Faxon (1998)
Cardiovasc Res 39, 50-59
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Application of Serial In Vivo Magnetic Resonance Imaging to Evaluate the Efficacy of Endothelin Receptor Antagonist SB 217242 in the Rat Carotid Artery Model of Neointima Formation.
S. Chandra, L. V. Clark, R. W. Coatney, L. Phan, S. K. Sarkar, and E. H. Ohlstein (1998)
Circulation 97, 2252-2258
   Abstract »    Full Text »    PDF »


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