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Science 7 July 1989:
Vol. 245. no. 4913, pp. 60 - 63
DOI: 10.1126/science.2662408
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Articles

Science, Vol 245, Issue 4913, 60-63
Copyright © 1989 by American Association for the Advancement of Science

articles

Pretranslational suppression of an insulin-responsive glucose transporter in rats with diabetes mellitus

WT Garvey, TP Huecksteadt, and MJ Birnbaum

Section of Endocrinology and Metabolism, VA Medical Center, Indianapolis, IN.

A prominent feature of diabetes mellitus is the inability of insulin to appropriately increase the transport of glucose into target tissues. The contributions of different glucose transport proteins to insulin resistance in rats with streptozotocin-induced diabetes was evaluated. A glucose transporter messenger RNA and its cognate protein that are exclusively expressed in muscle and adipose tissue were specifically depleted in diabetic animals, and these effects were reversed after insulin therapy; a different glucose transporter and its messenger RNA that exhibit a less restricted tissue distribution were not specifically modulated in this way. Depletion of the muscle- and adipose-specific glucose transporter species correlates with and may account for the major portion of cellular insulin resistance in diabetes in these animals.


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