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Science 16 June 1989:
Vol. 244. no. 4910, pp. 1360 - 1362
DOI: 10.1126/science.2660263

Articles

Science, Vol 244, Issue 4910, 1360-1362
Copyright © 1989 by American Association for the Advancement of Science


articles

Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs

JW Olney, J Labruyere, and MT Price

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.

Phencyclidine (PCP), a dissociative anesthetic and widely abused psychotomimetic drug, and MK-801, a potent PCP receptor ligand, have neuroprotective properties stemming from their ability to antagonize the excitotoxic actions of endogenous excitatory amino acids such as glutamate and aspartate. There is growing interest in the potential application of these compounds in the treatment of neurological disorders. However, there is an apparent neurotoxic effect of PCP and related agents (MK-801, tiletamine, and ketamine), which has heretofore been overlooked: these drugs induce acute pathomorphological changes in specific populations of brain neurons when administered subcutaneously to adult rats in relatively low doses. These findings raise new questions regarding the safety of these agents in the clinical management of neurodegenerative diseases and reinforce concerns about the potential risks associated with illicit use of PCP.


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