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Science 9 June 1989:
Vol. 244. no. 4909, pp. 1152 - 1157
DOI: 10.1126/science.2658060
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Articles

Science, Vol 244, Issue 4909, 1152-1157
Copyright © 1989 by American Association for the Advancement of Science

articles

The role of somatic hypermutation in the generation of antibody diversity

DL French, R Laskov, and MD Scharff

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461.

The immune system is capable of establishing an enormous repertoire of antibodies before its first contact with antigen. Most antibodies that express germ-line sequences are of relatively low affinity. Once antigen enters the system, it stimulates a somatic mutational mechanism that generates antibodies of higher affinity and selects for the expression of those antibodies to produce a more effective immune response. The details of the mechanism and regulation of somatic hypermutation remain to be elucidated.


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