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Science 19 May 1989:
Vol. 244. no. 4906, pp. 817 - 820
DOI: 10.1126/science.2658055
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Articles

Science, Vol 244, Issue 4906, 817-820
Copyright © 1989 by American Association for the Advancement of Science

articles

Class II MHC molecules are specific receptors for staphylococcus enterotoxin A

JA Mollick, RG Cook, and RR Rich

Howard Hughes Medical Institute Laboratory, Baylor College of Medicine, Houston, TX 77030.

T cell proliferation in response to stimulation with Staphylococcus enterotoxin A (SEA) requires accessory cells that express class II major histocompatibility complex (MHC) molecules. Murine fibroblasts transfected with genes encoding the alpha and beta subunits of HLA-DR, DQ, or DP were used to show that the proliferative response of purified human T cells to SEA is dependent on class II molecules but is not restricted by the haplotype of the responder. Binding of fluoresceinated SEA to class II transfectants and precipitation of class II heterodimers with SEA-Sepharose show that the proliferative response is a result of SEA binding to class II molecules. The binding is specific for class II molecules and is independent of class II allotype or isotype. The ability of SEA to bind class II molecules may be a general characteristic of this class of antigens, now called "superantigens".


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