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Science 12 May 1989:
Vol. 244. no. 4905, pp. 697 - 699
DOI: 10.1126/science.2717946
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Articles

Science, Vol 244, Issue 4905, 697-699
Copyright © 1989 by American Association for the Advancement of Science

articles

Calicheamicin gamma 1I and DNA: molecular recognition process responsible for site-specificity

N Zein, M Poncin, R Nilakantan, and GA Ellestad

Cyanamid Company, Medical Research Division, Lederle Laboratories, Pearl River, NY 10965.

Calicheamicin gamma 1I is a recently discovered diyne-ene-containing antitumor antibiotic that cleaves DNA in a double-stranded fashion, a rarity among drugs, at specific sequences. It is proposed that the cutting specificity is due to a combination of the complementarity of the diyne-ene portion of the aglycone with DNA secondary structures and stabilization by association of the thiobenzoate-carbohydrate tail with the minor groove.


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Efficacy and Safety of Gemtuzumab Ozogamicin in Patients With CD33-Positive Acute Myeloid Leukemia in First Relapse.
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Interaction of calicheamicin gamma 1I and its related carbohydrates with DNA-protein complexes.
C. Sissi, J. Aiyar, S. Boyer, K. Depew, S. Danishefsky, and D. M. Crothers (1999)
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Simultaneous determination of helical unwinding angles and intrinsic association constants in ligand-DNA complexes: The interaction between DNA and calichearubicin B.
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Sequence-specific isotope effects on the cleavage of DNA by bleomycin.
J. Kozarich, L Worth Jr, B. Frank, D. Christner, D. Vanderwall, and J Stubbe (1989)
Science 245, 1396-1399
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A continuous assay for DNA cleavage: The application of "break lights" to enediynes, iron-dependent agents, and nucleases.
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