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Science 21 April 1989:
Vol. 244. no. 4902, pp. 343 - 346
DOI: 10.1126/science.2711183
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Articles

Science, Vol 244, Issue 4902, 343-346
Copyright © 1989 by American Association for the Advancement of Science

articles

The role of cis-acting promoter elements in tissue-specific albumin gene expression

P Maire, J Wuarin, and U Schibler

Departement de Biologie Moleculaire, Sciences II, Geneva, Switzerland.

The mouse albumin gene promoter has six closely spaced binding sites for nuclear proteins that are located between the TATA motif and nucleotide position -170. In vitro transcription with liver or spleen nuclear extracts of templates containing either mutated or polymerized albumin promoter elements establishes a hierarchy of the different protein binding sites for tissue-specific albumin gene transcription. The HNF-1 and C/EBP binding sites strongly activate transcription in a tissue-specific manner. The NF-Y binding site has a lower activation potential and is less specific, being equally efficient in liver and spleen nuclear extracts. The remaining elements are relatively weak activator sites.


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