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Science 21 April 1989:
Vol. 244. no. 4902, pp. 339 - 343
DOI: 10.1126/science.2540528
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Articles

Science, Vol 244, Issue 4902, 339-343
Copyright © 1989 by American Association for the Advancement of Science

articles

Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway

T Lindstein, CH June, JA Ledbetter, G Stella, and CB Thompson

Howard Hughes Medical Institute, University of Michigan, Ann Arbor 48109.

Quiescent T cells can be induced to express many genes by mitogen or antigen stimulation. The messenger RNAs of some of these genes undergo relatively rapid degradation compared to messenger RNAs from constitutively expressed genes. A T cell activation pathway that specifically regulates the stability of messenger RNAs for the lymphokines interleukin-2, interferon-gamma, tumor necrosis factor-alpha, and granulocyte-macrophage colony-stimulating factor is induced by stimulation of the CD28 surface molecule. This pathway does not directly affect the steady-state messenger RNA level, transcription, or messenger RNA half-life of other T cell activation genes, including c-myc, c-fos, IL-2 receptor, and the 4F2HC surface antigen. These data show that stimuli received at the cell surface can alter gene expression by inducing specific changes in messenger RNA degradation.


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   Abstract »    Full Text »    PDF »
B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells.
S.-Y. Tseng, M. Otsuji, K. Gorski, X. Huang, J. E. Slansky, S. I. Pai, A. Shalabi, T. Shin, D. M. Pardoll, and H. Tsuchiya (2001)
J. Exp. Med. 193, 839-846
   Abstract »    Full Text »    PDF »
Antigen-Independent Th2 Cell Differentiation by Stimulation of CD28: Regulation Via IL-4 Gene Expression and Mitogen-Activated Protein Kinase Activation.
A. Skapenko, P. E. Lipsky, H.-G. Kraetsch, J. R. Kalden, and H. Schulze-Koops (2001)
J. Immunol. 166, 4283-4292
   Abstract »    Full Text »    PDF »
Granulocyte Macrophage-Colony-Stimulating Factor mRNA Is Stabilized in Airway Eosinophils and Peripheral Blood Eosinophils Activated by TNF-{{alpha}} Plus Fibronectin.
S. Esnault and J. S. Malter (2001)
J. Immunol. 166, 4658-4663
   Abstract »    Full Text »    PDF »
C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation.
K. Sabapathy, T. Kallunki, J.-P. David, I. Graef, M. Karin, and E. F. Wagner (2001)
J. Exp. Med. 193, 317-328
   Abstract »    Full Text »    PDF »
ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins.
T. Bakheet, M. Frevel, B. R. G. Williams, W. Greer, and K. S. A. Khabar (2001)
Nucleic Acids Res. 29, 246-254
   Abstract »    Full Text »    PDF »
Negative-Feedback Regulation of CD28 Costimulation by a Novel Mitogen-Activated Protein Kinase Phosphatase, MKP6.
F. Marti, A. Krause, N. H. Post, C. Lyddane, B. Dupont, M. Sadelain, and P. D. King (2001)
J. Immunol. 166, 197-206
   Abstract »    Full Text »    PDF »
Costimulation Light: Activation of CD4+ T Cells with CD80 or CD86 Rather Than Anti-CD28 Leads to a Th2 Cytokine Profile.
C. P. M. Broeren, G. S. Gray, B. M. Carreno, and C. H. June (2000)
J. Immunol. 165, 6908-6914
   Abstract »    Full Text »    PDF »
Intercellular Adhesion Molecule 1 Is Critical for Activation of CD28-Deficient T Cells.
J. L. Gaglia, E. A. Greenfield, A. Mattoo, A. H. Sharpe, G. J. Freeman, and V. K. Kuchroo (2000)
J. Immunol. 165, 6091-6098
   Abstract »    Full Text »    PDF »
Identification of a Complex that Binds to the CD154 3' Untranslated Region: Implications for a Role in Message Stability During T Cell Activation.
B. Barnhart, P. A. Kosinski, Z. Wang, G. S. Ford, M. Kiledjian, and L. R. Covey (2000)
J. Immunol. 165, 4478-4486
   Abstract »    Full Text »    PDF »
Protein Ligands to Hur Modulate Its Interaction with Target Mrnas in Vivo.
C. M. Brennan, I.-E. Gallouzi, and J. A. Steitz (2000)
J. Cell Biol. 151, 1-14
   Abstract »    Full Text »    PDF »
CD28 Utilizes Vav-1 to Enhance TCR-Proximal Signaling and NF-AT Activation.
F. Michel, G. Mangino, G. Attal-Bonnefoy, L. Tuosto, A. Alcover, A. Roumier, D. Olive, and O. Acuto (2000)
J. Immunol. 165, 3820-3829
   Abstract »    Full Text »    PDF »
Costimulation of T Cells.
L. BUGEON and M. J. DALLMAN (2000)
Am. J. Respir. Crit. Care Med. 162, S164-168
   Abstract »    Full Text »    PDF »
Characterisation of mucosal lymphoid aggregates in ulcerative colitis: immune cell phenotype and TcR-gamma delta expression.
M M-W Yeung, S Melgar, V Baranov, A Oberg, A Danielsson, S Hammarstrom, and M-L Hammarstrom (2000)
Gut 47, 215-227
   Abstract »    Full Text »    PDF »
Enhanced surface TCR replenishment mediated by CD28 leads to greater TCR engagement during primary stimulation.
A. G. Schrum, A. D. Wells, and L. A. Turka (2000)
Int. Immunol. 12, 833-842
   Abstract »    Full Text »    PDF »
Characterization of the mRNA ligands bound by the RNA binding protein hnRNP A2 utilizing a novel in vivo technique.
S. A. Brooks and W. F. C. Rigby (2000)
Nucleic Acids Res. 28, e49
   Abstract »    Full Text »    PDF »
Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation.
C.-Y. Chen, R. Gherzi, J. S. Andersen, G. Gaietta, K. Jürchott, H.-D. Royer, M. Mann, and M. Karin (2000)
Genes & Dev. 14, 1236-1248
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HuR binding to cytoplasmic mRNA is perturbed by heat shock.
I.-E. Gallouzi, C. M. Brennan, M. G. Stenberg, M. S. Swanson, A. Eversole, N. Maizels, and J. A. Steitz (2000)
PNAS 97, 3073-3078
   Abstract »    Full Text »    PDF »
The B7/CD28/CTLA4 T-Cell Activation Pathway . Implications for Inflammatory Lung Disease.
J. M. Green (2000)
Am. J. Respir. Cell Mol. Biol. 22, 261-264
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Mucosa-Specific Targets for Regulation of IFN-{gamma} Expression: Lamina Propria T Cells Use Different cis-Elements than Peripheral Blood T Cells to Regulate Transactivation of IFN-{gamma} Expression.
R. Gonsky, R. L. Deem, J. H. Bream, D. H. Lee, H. A. Young, and S. R. Targan (2000)
J. Immunol. 164, 1399-1407
   Abstract »    Full Text »    PDF »


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