Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 21 April 1989:
Vol. 244. no. 4902, pp. 329 - 331
DOI: 10.1126/science.2540527
Prev | Table of Contents | Next

Articles

Science, Vol 244, Issue 4902, 329-331
Copyright © 1989 by American Association for the Advancement of Science

articles

Template-directed oligomerization catalyzed by a polynucleotide analog

J Visscher, CG Bakker, R van der Woerd, and AW Schwartz

Laboratory for Exobiology, Faculty of Science, University of Nijmegen, The Netherlands.

A pyrophosphate-linked analog of polycytidylic acid has been synthesized and shown to catalyze the oligomerization of the complementary monomer 2'-deoxyguanosine 3',5'-bisphosphoimidazolide. Analogs of polynucleotides are of interest in studies of the origins of life as possible precursors of the first RNA molecules. These results demonstrate that such molecules are capable of serving as templates for further synthesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Was adenine the first purine?.
A. Schwartz and C. Bakker (1989)
Science 245, 1102-1104
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)