Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 24 March 1989:
Vol. 243. no. 4898, pp. 1596 - 1599
DOI: 10.1126/science.2928797
Prev | Table of Contents | Next

Articles

Science, Vol 243, Issue 4898, 1596-1599
Copyright © 1989 by American Association for the Advancement of Science

articles

Histamine is an intracellular messenger mediating platelet aggregation

SP Saxena, LJ Brandes, AB Becker, KJ Simons, FS LaBella, and JM Gerrard

Department of Pediatrics, University of Manitoba, Winnipeg, Canada.

Inhibition of human platelet aggregation by N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine-HCl (DPPE), a novel antagonist of histamine binding, suggested that histamine might serve a critical role in cell function. Phorbol-12-myristate-13-acetate (PMA) or collagen was found to increase platelet histamine content in parallel with promotion of aggregation. Inhibitors of histidine decarboxylase (HDC) suppressed both aggregation and the elevation of histamine content, whereas DPPE inhibited aggregation only. In saponin-permeabilized platelets, added histamine reversed the inhibition by DPPE or HDC inhibitors on aggregation induced by PMA or collagen. The results indicate a role for histamine as an intracellular messenger, which in platelets promotes aggregation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.
X. Xu, D. Zhang, H. Zhang, P. J. Wolters, N. P. Killeen, B. M. Sullivan, R. M. Locksley, C. A. Lowell, and G. H. Caughey (2006)
J. Exp. Med. 203, 2907-2917
   Abstract »    Full Text »    PDF »
Histamine Contributes to Ischemia-Related Activation of Cardiac Spinal Afferents: Role of H1 Receptors and PKC.
L.-W. Fu, W. Schunack, and J. C. Longhurst (2005)
J Neurophysiol 93, 713-722
   Abstract »    Full Text »    PDF »
Pharmacological Stabilization of Mast Cells Abrogates Late Thrombotic Events Induced by Diesel Exhaust Particles in Hamsters.
A. Nemmar, P. H.M. Hoet, J. Vermylen, B. Nemery, and M. F. Hoylaerts (2004)
Circulation 110, 1670-1677
   Abstract »    Full Text »    PDF »
Arthropod-Derived Histamine-Binding Protein Prevents Murine Allergic Asthma.
I. Couillin, I. Maillet, B. B. Vargaftig, M. Jacobs, G. C. Paesen, P. A. Nuttall, J. Lefort, R. Moser, W. Weston-Davies, and B. Ryffel (2004)
J. Immunol. 173, 3281-3286
   Abstract »    Full Text »    PDF »
Pulmonary Inflammation and Thrombogenicity Caused by Diesel Particles in Hamsters: Role of Histamine.
A. Nemmar, B. Nemery, P. H. M. Hoet, J. Vermylen, and M. F. Hoylaerts (2003)
Am. J. Respir. Crit. Care Med. 168, 1366-1372
   Abstract »    Full Text »    PDF »
Intracellular Localization of the 74- and 53-kDa Forms of L-Histidine Decarboxylase in a Rat Basophilic/Mast Cell Line, RBL-2H3.
S. Tanaka, K.-i. Nemoto, E. Yamamura, and A. Ichikawa (1998)
J. Biol. Chem. 273, 8177-8182
   Abstract »    Full Text »    PDF »
Novel Qualitative Structure-Activity Relationships for the Antinociceptive Actions of H2 Antagonists, H3 Antagonists and Derivatives.
L. B. Hough, J. W. Nalwalk, B. Y. Li, R. Leurs, W.M.P.B. Menge, H. Timmerman, M. E. Carlile, C. Cioffi, and M. Wentland (1997)
J. Pharmacol. Exp. Ther. 283, 1534-1543
   Abstract »    Full Text »
International Union of Pharmacology. XIII. Classification of Histamine Receptors.
S. J. Hill, C. R. Ganellin, H. Timmerman, J. C. Schwartz, N. P. Shankley, J. M. Young, W. Schunack, R. Levi, and H. L. Haas (1997)
Pharmacol. Rev. 49, 253-278
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)