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Science 24 March 1989:
Vol. 243. no. 4898, pp. 1564 - 1570
DOI: 10.1126/science.2538922
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Articles

Science, Vol 243, Issue 4898, 1564-1570
Copyright © 1989 by American Association for the Advancement of Science

articles

Signal transduction by the platelet-derived growth factor receptor

LT Williams

Howard Hughes Medical Institute, University of California, San Francisco 94143-0724.

When platelet-derived growth factor (PDGF) binds to its receptor on a quiescent fibroblast or smooth muscle cell, it stimulates a remarkably diverse group of biochemical responses, including changes in ion fluxes, activation of several kinases, alterations in cell shape, increased transcription of a number of genes, and stimulation of enzymes that regulate phospholipid metabolism. These and other reactions culminate, hours later, in DNA replication and cell division. How does the receptor for PDGF recognize and bind its specific ligand and then transduce this signal across the cell membrane via a single membrane-spanning region? Which of the immediate cellular responses are directly involved in the biochemical pathways that lead to DNA synthesis? How does the PDGF receptor trigger a diverse group of responses? Recent studies of the PDGF receptor have provided insight into these issues.


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