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Science 17 March 1989:
Vol. 243. no. 4897, pp. 1481 - 1483
DOI: 10.1126/science.243.4897.1481
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Articles

Identification of an Allatotropin from Adult Manduca Sexta

Hiroshi Kataoka 1, Anne Toschi 1, Jorge P. Li 1, Robert L. Carney 1, David A. Schooley 1, and Steven J. Kramer 1

1 Zoecon Research Institute, Sandoz Crop Protection Corporation, P.O. Box 10975, Palo Alto, CA 94303

A peptide that strongly stimulates the secretion of juvenile hormone from corpora allata in vitro (allatotropin) has been purified from extracts of heads of pharate adult Manduca sexta. The primary structure of this 13-residue peptide has been determined: H-Gly-Phe-Lys-Asn-Val-Glu-Met-Met-Thr-Ala-Arg-Gly-Phe-NH2. This neurohormone has no sequence similarity with any known neuropeptide from other organisms. Synthetic allatotropin, as well as truncation fragments, including one with the five amino terminal residues deleted, showed in vitro activity indistinguishable from that of native allatotropin.


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