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Science 17 March 1989:
Vol. 243. no. 4897, pp. 1474 - 1477
DOI: 10.1126/science.2467378
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Articles

Science, Vol 243, Issue 4897, 1474-1477
Copyright © 1989 by American Association for the Advancement of Science

articles

Quisqualate activates a rapidly inactivating high conductance ionic channel in hippocampal neurons

CM Tang, M Dichter, and M Morad

Department of Physiology, University of Pennsylvania, Philadelphia 19104.

Glutamate activates a number of different receptor-channel complexes, each of which may contribute to generation of excitatory postsynaptic potentials in the mammalian central nervous system. The rapid application of the selective glutamate agonist, quisqualate, activates a large rapidly inactivating current (3 to 8 milliseconds), which is mediated by a neuronal ionic channel with high unitary conductance (35 picosiemens). The current through this channel shows pharmacologic characteristics similar to those observed for the fast excitatory postsynaptic current (EPSC); it reverses near 0 millivolts and shows no significant voltage dependence. The amplitude of the current through this channel is many times larger than that through the other non-NMDA (N-methyl-D-aspartate) channels. These results suggest that this high-conductance quisqualate-activated channel may mediate the fast EPSC in the mammalian central nervous system.


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