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Science 17 March 1989:
Vol. 243. no. 4897, pp. 1450 - 1455
DOI: 10.1126/science.2648568
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Articles

Science, Vol 243, Issue 4897, 1450-1455
Copyright © 1989 by American Association for the Advancement of Science

articles

Glial cell diversification in the rat optic nerve

MC Raff

A central challenge in developmental neurobiology is to understand how an apparently homogeneous population of neuroepithelial cells in the early mammalian embryo gives rise to the great diversity of nerve cells (neurons) and supporting cells (glial cells) in the mature central nervous system. Because the optic nerve is one of the several types of glial cells but no intrinsic neurons, it is an attractive place to investigate how neuroepithelial cells diversify. Studies of developing rat optic nerve cells in culture suggest that both cell-cell interactions and intrinsic cellular programs play important parts in glial cell diversification.


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