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Science 10 February 1989:
Vol. 243. no. 4892, pp. 781 - 786
DOI: 10.1126/science.2492678
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Articles
Science, Vol 243, Issue 4892, 781-786
Copyright © 1989 by American Association for the Advancement of Science
Mechanism of interleukin-2 signaling: mediation of different outcomes by a single receptor and transduction pathway
MA Tigges,
LS Casey,
and
ME Koshland
Chiron Corporation, Emeryville, CA 94608.
The T cell lymphokine, interleukin-2 (IL-2), plays a pivotal role in an immune response by stimulating antigen-activated B lymphocytes to progress through the cell cycle and to differentiate into antibody-secreting cells. An IL-2 inducible B lymphoma line, in which the growth and differentiation responses are uncoupled, provides a model system for dissecting the signaling mechanisms operating in each response. This system was used to show that both signals are initiated by IL-2 binding to a single, unifunctional receptor complex. Moreover, both signals are transduced by a pathway that does not involve any known second messenger system and that can be blocked by a second T cell lymphokine, interleukin 4. These findings suggest that the pleiotrophic effects of IL-2 are determined by different translations of the signal in the nucleus.
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