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Science 20 January 1989:
Vol. 243. no. 4889, pp. 381 - 383
DOI: 10.1126/science.2911750
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Articles

Science, Vol 243, Issue 4889, 381-383
Copyright © 1989 by American Association for the Advancement of Science

articles

The involvement of platelet activating factor in ovulation

AO Abisogun, P Braquet, and A Tsafriri

Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.

Follicle rupture during ovulation is associated with inflammation-like changes. Because platelet activating factor (PAF) participates in the inflammatory process, the effect of a PAF-specific antagonist, BN52021, on the ovulatory response was tested in rats. BN52021, administered locally, inhibited follicle rupture in rats stimulated to ovulate with human chorionic gonadotropin (hCG). In addition to suppressing rupture of the follicles, this antagonist suppressed the hCG-stimulated increase in ovarian collagenolysis and vascular permeability. The inhibition of ovulation of BN52021 could be reversed by simultaneous administration of PAF. Furthermore, PAF partially reversed the blockage of ovulation by inhibitors of eicosanoid synthesis. Collectively, these results suggest the involvement of PAF in ovulation. Its role seems to be closely related to the metabolism of arachidonic acid. Thus, modulation of PAF action may serve as an additional target for regulation of reproduction via its action on ovulation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tumor Necrosis Factor-{alpha}-Induced Matrix Proteolytic Enzyme Production and Basement Membrane Remodeling by Human Ovarian Surface Epithelial Cells: Molecular Basis Linking Ovulation and Cancer Risk.
W.-L. Yang, A. K. Godwin, and X.-X. Xu (2004)
Cancer Res. 64, 1534-1540
   Abstract »    Full Text »    PDF »
Endocrine-Regulated and Protein Kinase C-Dependent Generation of Superoxide by Rat Preovulatory Follicles.
P. H. Kodaman and H. R. Behrman (2001)
Endocrinology 142, 687-693
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Production and Regulation of Cytokine-Induced Neutrophil Chemoattractant in Rat Ovulation.
K. Ushigoe, M. Irahara, M. Fukumochi, M. Kamada, and T. Aono (2000)
Biol Reprod 63, 121-126
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Inhibitory Effect of Interleukin-8 on the Secretion of Platelet-Activating Factor Acetylhydrolase by Human Decidual Macrophages.
Y. Kawano, H. Narahara, and J. M. Johnston (1999)
Reproductive Sciences 6, 328-332
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