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Science 13 January 1989:
Vol. 243. no. 4888, pp. 226 - 229
DOI: 10.1126/science.2911736
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Articles

Science, Vol 243, Issue 4888, 226-229
Copyright © 1989 by American Association for the Advancement of Science

articles

Dynamic expression pattern of the myc protooncogene in midgestation mouse embryos

P Schmid, WA Schulz, and H Hameister

Abteilung Klinische Genetik, Universitat Ulm, Federal Republic of Germany.

The c-myc protooncogene in mouse embryos was shown by RNA in situ hybridization to be preferentially expressed in tissues of endodermal and mesodermal origin. Most organs developing from the ectoderm, such as skin, brain, and spinal cord, displayed low levels of c-myc RNA. The thymus represented the only hematopoietic organ with high c-myc expression. In organs and structures strongly hybridizing to c-myc probes, for example the fetal part of the placenta, gut, liver, kidney, pancreas, submandibular glands, enamel organs of the molars, and skeletal cartilage, the level of expression depended on the stage of development. Expression was observed to be correlated with proliferation, particularly during expansion and folding of partially differentiated epithelial cells.


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