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Science 13 January 1989:
Vol. 243. no. 4888, pp. 212 - 214
DOI: 10.1126/science.2783496
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Articles

Science, Vol 243, Issue 4888, 212-214
Copyright © 1989 by American Association for the Advancement of Science

articles

A novel vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis

JM Ribeiro, A Vachereau, GB Modi, and RB Tesh

Department of Tropical Public Health, Harvard School of Public Health, Boston, MA 02115.

Salivary gland lysates of the sand fly Lutzomyia longipalpis contain a potent vasodilator that aids the fly to feed on the blood of its vertebrate hosts. Chromatographic analysis, antibody reactivity, and data obtained from bioassays of the salivary erythema-inducing factor indicate striking similarity with human calcitonin gene-related peptide. The erythema-inducing factor is, however, at least one order of magnitude more potent than calcitonin gene-related peptide.


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