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Science 6 January 1989:
Vol. 243. no. 4887, pp. 89 - 91
DOI: 10.1126/science.2536188
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Articles

Science, Vol 243, Issue 4887, 89-91
Copyright © 1989 by American Association for the Advancement of Science

articles

Transneuronal transfer of herpes virus from peripheral nerves to cortex and brainstem

G Ugolini, HG Kuypers, and PL Strick

Department of Anatomy, University of Cambridge, England.

The transneuronal transfer of neurotropic viruses may represent an effective tool for tracing chains of connected neurons because replication of virus in the recipient neurons after transfer amplifies the "tracer signal." Herpes simplex virus type 1 was transferred transneuronally from forelimb and hindlimb nerves of rats to the cortical and brainstem neurons that project to the spinal enlargements to which the nerves receiving injections are connected. This transneuronal transfer of herpes simplex virus type 1 from peripheral nerves has the potential to be used to identify neurons in the brain that are related transsynaptically to different nerves and muscles.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Efficient Reactivation of Latent Herpes Simplex Virus from Mouse Central Nervous System Tissues.
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Neuronal Premotor Networks Involved in Eyelid Responses: Retrograde Transneuronal Tracing with Rabies Virus from the Orbicularis Oculi Muscle in the Rat.
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Retrograde Transport of Transmissible Mink Encephalopathy within Descending Motor Tracts.
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Neuronal pathways for the propagation of herpes simplex virus type 1 from one retina to the other in a murine model.
M. Labetoulle, P. Kucera, G. Ugolini, F. Lafay, E. Frau, H. Offret, and A. Flamand (2000)
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Expression from the herpes simplex virus type 1 latency-associated promoter in the murine central nervous system.
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Gene Therapy for Neurologic Disease.
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J. Hoover and P. Strick (1993)
Science 259, 819-821
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