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Science 23 December 1988:
Vol. 242. no. 4886, pp. 1694 - 1697
DOI: 10.1126/science.2904701
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Articles

Science, Vol 242, Issue 4886, 1694-1697
Copyright © 1988 by American Association for the Advancement of Science

articles

Contributions of quisqualate and NMDA receptors to the induction and expression of LTP

D Muller, M Joly, and G Lynch

Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717.

The contributions of two subclasses of excitatory amino acid transmitter receptors to the induction and expression of long-term potentiation (LTP) were analyzed in hippocampal slices. The quisqualate/kainate receptor antagonist DNQX (6,7-dinitro-quinoxaline-2,3-dione) blocked 85% of the evoked field potential, leaving a small response that was sensitive to D-AP5 (D-2-amino-5-phosphonopentanoate), an N-methyl-D-aspartate (NMDA) receptor blocker. This residual D-AP5-sensitive response was of comparable size in control and previously potentiated inputs. High-frequency stimulation in the presence of DNQX did not result in the development of robust LTP. Washout of the drug, however, revealed the potentiation effect. Thus NMDA-mediated responses can induce, but are not greatly affected by, LTP; non-NMDA receptors, conversely, mediate responses that are not needed to elicit LTP but that are required for its expression.


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