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Science 23 September 1988:
Vol. 241. no. 4873, pp. 1673 - 1675
DOI: 10.1126/science.3047875
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Articles

Science, Vol 241, Issue 4873, 1673-1675
Copyright © 1988 by American Association for the Advancement of Science

articles

Cytokines alter production of HIV-1 from primary mononuclear phagocytes

Y Koyanagi, WA O'Brien, JQ Zhao, DW Golde, JC Gasson, and IS Chen

Department of Microbiology and Immunology, UCLA School of Medicine 90024.

Some strains of human immunodeficiency virus type 1 (HIV-1) can infect primary monocytes and monocyte-derived macrophages in vitro. In this report, the effect of cytokines on the production of one of these strains that shows a tropism for mononuclear phagocytes, designated HIV-1JR-FL, was studied. Primary peripheral blood mononuclear phagocytes infected with HIV-1JR-FL were treated with the hematopoietic factors: granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), macrophage colony-stimulating factor (M-CSF), and gamma-interferon (gamma-IFN). The M-CSF, GM-CSF, IL-3, and gamma-IFN were able to alter HIV-1 production under different conditions.


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