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Science 19 August 1988:
Vol. 241. no. 4868, pp. 978 - 981
DOI: 10.1126/science.3406747
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Articles

Science, Vol 241, Issue 4868, 978-981
Copyright © 1988 by American Association for the Advancement of Science

articles

Coordinate hormonal and synaptic regulation of vasopressin messenger RNA

F Baldino Jr, TM O'Kane, S Fitzpatrick-McElligott, and B Wolfson

Medical Products Department, E. I. du Pont de Nemours & Company, Wilmington, DE 19898.

Previous studies have shown that adrenalectomy augments arginine vasopressin (AVP) messenger RNA levels in the adult paraventricular nucleus. It is now demonstrated that unilateral lesions in the lateral septal nucleus enhance the adrenalectomy-induced expression of AVP mRNA. This effect was entirely ipsilateral to the lesion and most prominent in the rostral paraventricular nucleus and related nuclei. Moreover, AVP and AVP mRNA were found to be colocalized with oxytocin in a few neurons. These results indicate that mRNA expression is modulated by synaptic influences and raise the possibility that synaptically mediated selection of neuronal phenotypes is a dynamic feature of the mature central nervous system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of Vasopressin Gene Expression by cAMP and Glucocorticoids in Parvocellular Neurons of the Paraventricular Nucleus in Rat Hypothalamic Organotypic Cultures.
S. Kuwahara, H. Arima, R. Banno, I. Sato, N. Kondo, and Y. Oiso (2003)
J. Neurosci. 23, 10231-10237
   Abstract »    Full Text »    PDF »
Gene Regulation in the Magnocellular Hypothalamo-Neurohypophysial System.
J. P. H. Burbach, S. M. Luckman, D. Murphy, and H. Gainer (2001)
Physiol Rev 81, 1197-1267
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The V1a and V1b, But Not V2, Vasopressin Receptor Genes Are Expressed in the Supraoptic Nucleus of the Rat Hypothalamus, and the Transcripts Are Essentially Colocalized in the Vasopressinergic Magnocellular Neurons.
A. Hurbin, L. Boissin-Agasse, H. Orcel, A. Rabie, N. Joux, M. G. Desarmenien, P. Richard, and F. C. Moos (1998)
Endocrinology 139, 4701-4707
   Abstract »    Full Text »    PDF »


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