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Science 15 July 1988:
Vol. 241. no. 4863, pp. 344 - 346
DOI: 10.1126/science.3388045
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Articles

Science, Vol 241, Issue 4863, 344-346
Copyright © 1988 by American Association for the Advancement of Science

articles

Long lives for homozygous trembler mutant mice despite virtual absence of peripheral nerve myelin

EW Henry and RL Sidman

Department of Neuropathology, Harvard Medical School, Boston, MA 02115.

Nervous system functions are dependent on point-to-point communication of signals along neuronal axons, and axonal insulation by myelin is thought to speed such conduction. Loss of previously formed myelin or lack of myelin formation can have serious, even fatal, consequences. Mice homozygous for the trembler mutation make virtually no peripheral nervous system myelin, yet have long and functional lives. This result calls into question the view that peripheral nervous system myelin plays a vital role, at least in this species.


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