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Science 8 July 1988:
Vol. 241. no. 4862, pp. 205 - 208
DOI: 10.1126/science.2968651
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Articles
Science, Vol 241, Issue 4862, 205-208
Copyright © 1988 by American Association for the Advancement of Science
A transcriptional enhancer 3' of C beta 2 in the T cell receptor beta locus
S McDougall,
CL Peterson,
and
K Calame
Department of Biological Chemistry, UCLA School of Medicine 90024.
Run-on transcription experiments were used to demonstrate that transcription of T cell receptor beta chain V genes is activated by DNA rearrangement, in a manner similar to immunoglobulin genes. A transcriptional enhancer likely to be involved in this activation has been identified. A 25-kilobase region from J beta 1 to V beta 14 was tested for enhancer activity by transient transfections, and an enhancer was found 7.5 kilobases 3' of C beta 2. The beta enhancer has low activity relative to the simian virus 40 viral enhancer, does not display a preference for V beta promoters, has a T cell-specific activity, and binds two purified immunoglobulin heavy chain enhancer factors.
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