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Science 24 June 1988:
Vol. 240. no. 4860, pp. 1772 - 1774
DOI: 10.1126/science.3381100
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Articles

Science, Vol 240, Issue 4860, 1772-1774
Copyright © 1988 by American Association for the Advancement of Science

articles

Regeneration of sensory hair cells after acoustic trauma

JT Corwin and DA Cotanche

Department of Zoology, University of Hawaii, Honolulu 96822.

Any loss of cochlear hair cells has been presumed to result in a permanent hearing deficit because the production of these cells normally ceases before birth. However, after acoustic trauma, injured sensory cells in the mature cochlea of the chicken are replaced. New cells appear to be produced by mitosis of supporting cells that survive at the lesion site and do not divide in the absence of trauma. This trauma-induced division of normally postmitotic cells may lead to recovery from profound hearing loss.


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