Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 10 June 1988:
Vol. 240. no. 4858, pp. 1439 - 1443
DOI: 10.1126/science.3287619

Articles

Science, Vol 240, Issue 4858, 1439-1443
Copyright © 1988 by American Association for the Advancement of Science


articles

Yeast: an experimental organism for modern biology

D Botstein and GR Fink

Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.

The yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe have become popular and successful model systems for understanding eukaryotic biology at the cellular and molecular levels. The reasons for this success are experimental tractability, especially in applying classical and molecular genetic methods to associate genes with proteins and functions within the cell.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Generation of Medaka Fish Haploid Embryonic Stem Cells.
M. Yi, N. Hong, and Y. Hong (2009)
Science 326, 430-433
   Abstract »    Full Text »    PDF »
Comparative Genomic Hybridization Provides New Insights Into the Molecular Taxonomy of the Saccharomyces Sensu Stricto Complex.
L. C. Edwards-Ingram, M. E. Gent, D. C. Hoyle, A. Hayes, L. I. Stateva, and S. G. Oliver (2004)
Genome Res. 14, 1043-1051
   Abstract »    Full Text »    PDF »
Expression of the Cymbidium Ringspot Virus 33-Kilodalton Protein in Saccharomyces cerevisiae and Molecular Dissection of the Peroxisomal Targeting Signal.
B. Navarro, L. Rubino, and M. Russo (2004)
J. Virol. 78, 4744-4752
   Abstract »    Full Text »    PDF »
Replication of Carnation Italian Ringspot Virus Defective Interfering RNA in Saccharomyces cerevisiae.
V. Pantaleo, L. Rubino, and M. Russo (2003)
J. Virol. 77, 2116-2123
   Abstract »    Full Text »    PDF »
A Streamlined Process to Phenotypically Profile Heterologous cDNAs in Parallel Using Yeast Cell-Based Assays.
S. Tugendreich, E. Perkins, J. Couto, P. Barthmaier, D. Sun, S. Tang, S. Tulac, A. Nguyen, E. Yeh, A. Mays, et al. (2001)
Genome Res. 11, 1899-1912
   Abstract »    Full Text »    PDF »
Metabolic Engineering of Saccharomyces cerevisiae.
S. Ostergaard, L. Olsson, and J. Nielsen (2000)
Microbiol. Mol. Biol. Rev. 64, 34-50
   Abstract »    Full Text »    PDF »
Comparison of the Complete Protein Sets of Worm and Yeast: Orthology and Divergence.
S. A. Chervitz, L. Aravind, G. Sherlock, C. A. Ball, E. V. Koonin, S. S. Dwight, M. A. Harris, K. Dolinski, S. Mohr, T. Smith, et al. (1998)
Science 282, 2022-2028
   Abstract »    Full Text »
Molecular linguistics: Extracting information from gene and protein sequences.
D. Botstein and J. M. Cherry (1997)
PNAS 94, 5506-5507
   Full Text »    PDF »
Yeast site-specific ribonucleoprotein endoribonuclease MRP contains an RNA component homologous to mammalian RNase MRP RNA and essential for cell viability..
M E Schmitt and D A Clayton (1992)
Genes & Dev. 6, 1975-1985
   Abstract »    PDF »
A group of interacting yeast DNA replication genes..
K M Hennessy, A Lee, E Chen, and D Botstein (1991)
Genes & Dev. 5, 958-969
   Abstract »    PDF »
Genetic Suppression Analysis of the Function of a Protein Kinase C (PKC1 Gene Product) in Saccharomyces cerevisiae Cell Cycle Progression: The SKCd Mutations.
F.O. Fields and J. Thorner (1991)
Cold Spring Harb Symp Quant Biol 56, 51-60
   Abstract »    PDF »
Yeast Spindle Pole Body Components.
M.P. Rout and J.V. Kilmartin (1991)
Cold Spring Harb Symp Quant Biol 56, 687-692
   Abstract »    PDF »
Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells.
P. Schwartzberg, S. Goff, and E. Robertson (1989)
Science 246, 799-803
   Abstract »    PDF »
Mapping the Drosophila genome with yeast artificial chromosomes.
D Garza, J. Ajioka, D. Burke, and D. Hartl (1989)
Science 246, 641-646
   Abstract »    PDF »
Isolation of single-copy human genes from a library of yeast artificial chromosome clones.
B. Brownstein, G. Silverman, R. Little, D. Burke, S. Korsmeyer, D Schlessinger, and M. Olson (1989)
Science 244, 1348-1351
   Abstract »    PDF »
Diverse Biological Functions of Small GTP-binding Proteins in Yeast.
D. Botstein, N. Segev, T. Stearns, M.A. Hoyt, J. Holden, and R.A. KAHN (1988)
Cold Spring Harb Symp Quant Biol 53, 629-636
   Abstract »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)