Science 3 June 1988: Vol. 240. no. 4857, pp. 1310 - 1316 DOI: 10.1126/science.2836950

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Articles

Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors.

T. E. Angel, M. R. Chance, and K. Palczewski (2009)
PNAS 106, 8555-8560
 |  Abstract »  |  Full Text »  |  PDF »

Identification of two distinct inactive conformations of the {beta}2-adrenergic receptor reconciles structural and biochemical observations.

R. O. Dror, D. H. Arlow, D. W. Borhani, M. O. Jensen, S. Piana, and D. E. Shaw (2009)
PNAS 106, 4689-4694
 |  Abstract »  |  Full Text »  |  PDF »

Role of {beta}-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease.

G. S. Lynch and J. G. Ryall (2008)
Physiol Rev 88, 729-767
 |  Abstract »  |  Full Text »  |  PDF »

GPCR Engineering Yields High-Resolution Structural Insights into 2-Adrenergic Receptor Function.

D. M. Rosenbaum, V. Cherezov, M. A. Hanson, S. G. F. Rasmussen, F. S. Thian, T. S. Kobilka, H.-J. Choi, X.-J. Yao, W. I. Weis, R. C. Stevens, et al. (2007)
Science 318, 1266-1273
 |  Abstract »  |  Full Text »  |  PDF »

Structural insights into the role of the ACTH receptor cysteine residues on receptor function.

Y. Yang, M. Chen, R. A. Kesterson Jr., and C. M. Harmon (2007)
Am J Physiol Regulatory Integrative Comp Physiol 293, R1120-R1126
 |  Abstract »  |  Full Text »  |  PDF »

A Comprehensive Structure-Function Map of the Intracellular Surface of the Human C5a Receptor: II. ELUCIDATION OF G PROTEIN SPECIFICITY DETERMINANTS.

M. L. Matsumoto, K. Narzinski, G. V. Nikiforovich, and T. J. Baranski (2007)
J. Biol. Chem. 282, 3122-3133
 |  Abstract »  |  Full Text »  |  PDF »

A Membrane-Permeable Peptide Containing the Last 21 Residues of the G{alpha}S Carboxyl Terminus Inhibits GS-Coupled Receptor Signaling in Intact Cells: Correlations between Peptide Structure and Biological Activity.

A. M. D'Ursi, L. Giusti, S. Albrizio, F. Porchia, C. Esposito, G. Caliendo, C. Gargini, E. Novellino, A. Lucacchini, P. Rovero, et al. (2006)
Mol. Pharmacol. 69, 727-736
 |  Abstract »  |  Full Text »  |  PDF »

The role of extra-membranous inter-helical loops in helix-helix interactions.

M. B. Ulmschneider, D.P. Tieleman, and M. S.P. Sansom (2005)
Protein Eng. Des. Sel. 18, 563-570
 |  Abstract »  |  Full Text »  |  PDF »

Arginine Residue 155 in the Second Intracellular Loop Plays a Critical Role in Rat Melanin-Concentrating Hormone Receptor 1 Activation.

Y. Saito, M. Tetsuka, S. Saito, K. Imai, A. Yoshikawa, H. Doi, and K. Maruyama (2005)
Endocrinology 146, 3452-3462
 |  Abstract »  |  Full Text »  |  PDF »

A Highly Conserved Glycine within Linker I and the Extreme C Terminus of G Protein {alpha} Subunits Interact Cooperatively in Switching G Protein-Coupled Receptor-to-Effector Specificity.

E. Kostenis, L. Martini, J. Ellis, M. Waldhoer, A. Heydorn, M. M. Rosenkilde, P. K. Norregaard, R. Jorgensen, J. L. Whistler, and G. Milligan (2005)
J. Pharmacol. Exp. Ther. 313, 78-87
 |  Abstract »  |  Full Text »  |  PDF »

The Receptor Concept: A Continuing Evolution.

L. E. Limbird (2004)
Mol. Interv. 4, 326-336
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Interactions between Transmembrane Helices Generate the Oligomeric {alpha}1b-Adrenoceptor.

J. J. Carrillo, J. F. Lopez-Gimenez, and G. Milligan (2004)
Mol. Pharmacol. 66, 1123-1137
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Novel Site within G Protein {alpha} Subunits Important for Specificity of Receptor-G Protein Interaction.

A. Heydorn, R. J. Ward, R. Jorgensen, M. M. Rosenkilde, T. M. Frimurer, G. Milligan, and E. Kostenis (2004)
Mol. Pharmacol. 66, 250-259
 |  Abstract »  |  Full Text »  |  PDF »

Probing Receptor Structure/Function with Chimeric G-Protein-Coupled Receptors.

D. Yin, S. Gavi, H.-y. Wang, and C. C. Malbon (2004)
Mol. Pharmacol. 65, 1323-1332
 |  Abstract »  |  Full Text »  |  PDF »

More Hints on Wnts: Gene Profiling by {beta}2-Adrenergic Receptor-Frizzled Chimeras.

D. Rosskopf and K. H. Jakobs (2004)
Mol. Pharmacol. 65, 12-14
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The Third Intracellular Loop and the Carboxyl Terminus of {beta}2-Adrenergic Receptor Confer Spontaneous Activity of the Receptor.

K. Chakir, Y. Xiang, D. Yang, S.-J. Zhang, H. Cheng, B. K. Kobilka, and R.-P. Xiao (2003)
Mol. Pharmacol. 64, 1048-1058
 |  Abstract »  |  Full Text »  |  PDF »

An Unusual Form of the Association Binding Kinetics of N-[3H]Methylscopolamine to the Split Muscarinic M2trunk/M2tail Receptor.

F. Novi, M. Scarselli, G. U. Corsini, and R. Maggio (2003)
J. Pharmacol. Exp. Ther. 305, 786-795
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Coupling of a Chimeric Dopamine D2/alpha 1B Receptor to the Phospholipase C Pathway: Inverse Agonism to Silent Antagonism by Neuroleptic Drugs.

T. Wurch, E. A. Boutet-Robinet, C. Palmier, F. C. Colpaert, and P. J. Pauwels (2003)
J. Pharmacol. Exp. Ther. 304, 380-390
 |  Abstract »  |  Full Text »  |  PDF »

The Extracellular N-terminal Domain and Transmembrane Domains 1 and 2 Mediate Oligomerization of a Yeast G Protein-coupled Receptor.

M. C. Overton and K. J. Blumer (2002)
J. Biol. Chem. 277, 41463-41472
 |  Abstract »  |  Full Text »  |  PDF »

Selective Inhibition of Heterotrimeric Gs Signaling. TARGETING THE RECEPTOR-G PROTEIN INTERFACE USING A PEPTIDE MINIGENE ENCODING THE Galpha s CARBOXYL TERMINUS.

D. S. Feldman, A. M. Zamah, K. L. Pierce, W. E. Miller, F. Kelly, A. Rapacciuolo, H. A. Rockman, W. J. Koch, and L. M. Luttrell (2002)
J. Biol. Chem. 277, 28631-28640
 |  Abstract »  |  Full Text »  |  PDF »

Determinants of the trans-Dominant Negative Effect of Truncated Forms of the CCR5 Chemokine Receptor.

M. Chelli and M. Alizon (2001)
J. Biol. Chem. 276, 46975-46982
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of Parathyroid Hormone (PTH)/Secretin Receptor Chimeras Differentiates the Role of Functional Domains in the PTH/ PTH-Related Peptide (PTHrP) Receptor on Hormone Binding and Receptor Activation.

J.-P. Vilardaga, I. Lin, and R. A. Nissenson (2001)
Mol. Endocrinol. 15, 1186-1199
 |  Abstract »  |  Full Text »  |  PDF »

Identification of G Protein-Coupled, Inward Rectifier Potassium Channel Gene Products from the Rat Anterior Pituitary Gland.

K. A. Gregerson, T. P. Flagg, T. J. O'Neill, M. Anderson, O. Lauring, J. S. Horel, and P. A. Welling (2001)
Endocrinology 142, 2820-2832
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Cell Surface Expression by Mutant Receptors Demonstrates that D2 Dopamine Receptors Exist as Oligomers in the Cell.

S. P. Lee, B. F. O'Dowd, G. Y.K. Ng, G. Varghese, H. Akil, A. Mansour, T. Nguyen, and S. R. George (2000)
Mol. Pharmacol. 58, 120-128
 |  Abstract »  |  Full Text »

Dopamine Receptors: Novel Insights from Biochemical and Genetic Studies.

C. Schmauss (2000)
Neuroscientist 6, 127-138
 |  Abstract »  |  PDF »

Chimeric and Point-Mutated Receptors Reveal That a Single Glycine Residue in Transmembrane Domain 6 Is Critical for High Affinity Melatonin Binding.

A. K. Gubitz and S. M. Reppert (2000)
Endocrinology 141, 1236-1244
 |  Abstract »  |  Full Text »  |  PDF »

Interactions of the Sulfonylurea Receptor 1 Subunit in the Molecular Assembly of beta -Cell KATP Channels.

M. V. Mikhailov and S. J. H. Ashcroft (2000)
J. Biol. Chem. 275, 3360-3364
 |  Abstract »  |  Full Text »  |  PDF »

Role of Transmembrane Helix IV in G-protein Specificity of the Angiotensin II Type 1 Receptor.

Y.-H. Feng and S. S. Karnik (1999)
J. Biol. Chem. 274, 35546-35552
 |  Abstract »  |  Full Text »  |  PDF »

Activation of a Frizzled-2/beta -adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galpha o and Galpha t.

X. Liu, T. Liu, D. C. Slusarski, J. Yang-Snyder, C. C. Malbon, R. T. Moon, and H.-y. Wang (1999)
PNAS 96, 14383-14388
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of G-protein-coupled Receptor Function by Disruption of Transmembrane Domain Interactions.

N. I. Tarasova, W. G. Rice, and C. J. Michejda (1999)
J. Biol. Chem. 274, 34911-34915
 |  Abstract »  |  Full Text »  |  PDF »

Dopamine D4/D2 Receptor Selectivity Is Determined by A Divergent Aromatic Microdomain Contained within the Second, Third, and Seventh Membrane-Spanning Segments.

M. M. Simpson, J. A. Ballesteros, V. Chiappa, J. Chen, M. Suehiro, D. S. Hartman, T. Godel, L. A. Snyder, T. P. Sakmar, and J. A. Javitch (1999)
Mol. Pharmacol. 56, 1116-1126
 |  Abstract »  |  Full Text »

Recent Advances in Cardiac {beta}2-Adrenergic Signal Transduction.

R.-P. Xiao, H. Cheng, Y.-Y. Zhou, M. Kuschel, and E. G. Lakatta (1999)
Circ. Res. 85, 1092-1100
 |  Abstract »  |  Full Text »  |  PDF »

Delineation of the Structural Basis for the Activation Properties of the Dopamine D1 Receptor Subtypes.

R. M. Iwasiow, M.-F. Nantel, and M. Tiberi (1999)
J. Biol. Chem. 274, 31882-31890
 |  Abstract »  |  Full Text »  |  PDF »

G Protein-Linked Receptors: Pharmacological Evidence for the Formation of Heterodimers.

R. Maggio, P. Barbier, A. Colelli, F. Salvadori, G. Demontis, and G. U. Corsini (1999)
J. Pharmacol. Exp. Ther. 291, 251-257
 |  Abstract »  |  Full Text »

An Engineered Cytochrome b6c1 Complex with a Split Cytochrome b Is Able To Support Photosynthetic Growth of Rhodobacter capsulatus.

A. S. Saribas, S. Mandaci, and F. Daldal (1999)
J. Bacteriol. 181, 5365-5372
 |  Abstract »  |  Full Text »

Importance of the Extracellular Domain for Prostaglandin EP2 Receptor Function.

B. A. Stillman, M. D. Breyer, and R. M. Breyer (1999)
Mol. Pharmacol. 56, 545-551
 |  Abstract »  |  Full Text »

Regulation of beta -Adrenoceptor Signaling in Cardiac Function and Disease.

N. Dzimiri (1999)
Pharmacol. Rev. 51, 465-502
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Molecular Characterization of m3 Muscarinic Receptor Dimers.

F.-Y. Zeng and J. Wess (1999)
J. Biol. Chem. 274, 19487-19497
 |  Abstract »  |  Full Text »  |  PDF »

Use of a Disulfide Cross-linking Strategy to Study Muscarinic Receptor Structure and Mechanisms of Activation.

F.-Y. Zeng, A. Hopp, A. Soldner, and J. Wess (1999)
J. Biol. Chem. 274, 16629-16640
 |  Abstract »  |  Full Text »  |  PDF »

Modularity of Serpins. A BIFUNCTIONAL CHIMERA POSSESSING alpha 1-PROTEINASE INHIBITOR AND THYROXINE-BINDING GLOBULIN PROPERTIES.

H. Grasberger, C. Buettner, and O. E. Janssen (1999)
J. Biol. Chem. 274, 15046-15051
 |  Abstract »  |  Full Text »  |  PDF »

beta -Arrestin-dependent Desensitization of Luteinizing Hormone/Choriogonadotropin Receptor Is Prevented by a Synthetic Peptide Corresponding to the Third Intracellular Loop of the Receptor.

S. Mukherjee, K. Palczewski, V. V. Gurevich, and M. Hunzicker-Dunn (1999)
J. Biol. Chem. 274, 12984-12989
 |  Abstract »  |  Full Text »  |  PDF »

Domains Determining Ligand Specificity for Ca2+ Receptors.

L. G. Hammerland, K. J. Krapcho, J. E. Garrett, N. Alasti, B. C. P. Hung, R. T. Simin, C. Levinthal, E. F. Nemeth, and F. H. Fuller (1999)
Mol. Pharmacol. 55, 642-648
 |  Abstract »  |  Full Text »

The Thrombospondin Receptor Integrin-associated Protein (CD47) Functionally Couples to Heterotrimeric Gi.

W. A. Frazier, A.-G. Gao, J. Dimitry, J. Chung, E. J. Brown, F. P. Lindberg, and M. E. Linder (1999)
J. Biol. Chem. 274, 8554-8560
 |  Abstract »  |  Full Text »  |  PDF »

Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function.

M. Bai, S. Trivedi, O. Kifor, S. J. Quinn, and E. M. Brown (1999)
PNAS 96, 2834-2839
 |  Abstract »  |  Full Text »  |  PDF »

Use of a Sandwich Enzyme-linked Immunosorbent Assay Strategy to Study Mechanisms of G Protein-coupled Receptor Assembly.

J. Jakubik and J. Wess (1999)
J. Biol. Chem. 274, 1349-1358
 |  Abstract »  |  Full Text »  |  PDF »

Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah.

Y. Lin, L. Seroude, and S. Benzer (1998)
Science 282, 943-946
 |  Abstract »  |  Full Text »

Mediation of Cyclic AMP Signaling by the First Intracellular Loop of the Gonadotropin-releasing Hormone Receptor.

K. K. Arora, L. Z. Krsmanovic, N. Mores, H. O'Farrell, and K. J. Catt (1998)
J. Biol. Chem. 273, 25581-25586
 |  Abstract »  |  Full Text »  |  PDF »

Alternative Splicing of the D2 Dopamine Receptor Messenger Ribonucleic Acid Is Modulated by Activated Sex Steroid Receptors in the MMQ Prolactin Cell Line.

D. Guivarc'h, J.-D. Vincent, and P. Vernier (1998)
Endocrinology 139, 4213-4221
 |  Abstract »  |  Full Text »  |  PDF »

Targeting of G Protein-coupled Receptors to the Basolateral Surface of Polarized Renal Epithelial Cells Involves Multiple, Non-contiguous Structural Signals.

C. Saunders, J. R. Keefer, C. A. Bonner, and L. E. Limbird (1998)
J. Biol. Chem. 273, 24196-24206
 |  Abstract »  |  Full Text »  |  PDF »

Chimeric Melanocortin MC1 and MC3 Receptors: Identification of Domains Participating in Binding of Melanocyte-Stimulating Hormone Peptides.

H. B. Schiöth, P. Yook, R. Muceniece, J. E. S. Wikberg, and M. Szardenings (1998)
Mol. Pharmacol. 54, 154-161
 |  Abstract »  |  Full Text »

Identification of Binding Domains of the Growth Hormone-Releasing Hormone Receptor by Analysis of Mutant and Chimeric Receptor Proteins.

V. I. DeAlmeida and K. E. Mayo (1998)
Mol. Endocrinol. 12, 750-765
 |  Abstract »  |  Full Text »

Refolding of Bacteriorhodopsin from Expressed Polypeptide Fragments.

T. Marti (1998)
J. Biol. Chem. 273, 9312-9322
 |  Abstract »  |  Full Text »  |  PDF »

Melanopsin: An opsin in melanophores, brain, and eye.

I. Provencio, G. Jiang, W. J. De Grip, W. P. Hayes, and M. D. Rollag (1998)
PNAS 95, 340-345
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Activity of a Chimeric D2/D1 Dopamine Receptor.

L. B. Kozell and K. A. Neve (1997)
Mol. Pharmacol. 52, 1137-1149
 |  Abstract »  |  Full Text »

Expression of Dopamine D3 Receptor Dimers and Tetramers in Brain and in Transfected Cells.

E. A. Nimchinsky, P. R. Hof, W. G. M. Janssen, J. H. Morrison, and C. Schmauss (1997)
J. Biol. Chem. 272, 29229-29237
 |  Abstract »  |  Full Text »  |  PDF »

Dimerization of the delta  Opioid Receptor:. IMPLICATION FOR A ROLE IN RECEPTOR INTERNALIZATION.

S. Cvejic and L. A. Devi (1997)
J. Biol. Chem. 272, 26959-26964
 |  Abstract »  |  Full Text »  |  PDF »

Co-expression of Defective Luteinizing Hormone Receptor Fragments Partially Reconstitutes Ligand-induced Signal Generation.

Y. Osuga, M. Hayashi, M. Kudo, M. Conti, B. Kobilka, and A. J. W. Hsueh (1997)
J. Biol. Chem. 272, 25006-25012
 |  Abstract »  |  Full Text »  |  PDF »

Reconstitution of Functional Voltage-gated Chloride Channels from Complementary Fragments of CLC-1.

T. Schmidt-Rose and T. J. Jentsch (1997)
J. Biol. Chem. 272, 20515-20521
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Gonadotropin-Releasing Hormone Receptor Signaling by Expression of a Splice Variant of the Human Receptor.

R. Grosse, T. Schöneberg, G. Schultz, and T. Gudermann (1997)
Mol. Endocrinol. 11, 1305-1318
 |  Abstract »  |  Full Text »

Both Overlapping and Distinct Signaling Pathways for Somatostatin Receptor Subtypes SSTR1 and SSTR2 in Pituitary Cells.

L. Chen, V. D. Fitzpatrick, R. L. Vandlen, and A. H. Tashjian Jr. (1997)
J. Biol. Chem. 272, 18666-18672
 |  Abstract »  |  Full Text »  |  PDF »

Concurrent Stimulation of Cannabinoid CB1 and Dopamine D2 Receptors Augments cAMP Accumulation in Striatal Neurons: Evidence for a Gs Linkage to the CB1 Receptor.

M. Glass and C. C. Felder (1997)
J. Neurosci. 17, 5327-5333
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Domains Conferring Ligand Binding Specificity to the Prostanoid Receptor. STUDIES ON CHIMERIC PROSTACYCLIN/PROSTAGLANDIN D RECEPTORS.

T. Kobayashi, M. Kiriyama, T. Hirata, M. Hirata, F. Ushikubi, and S. Narumiya (1997)
J. Biol. Chem. 272, 15154-15160
 |  Abstract »  |  Full Text »  |  PDF »

The Second Intracellular Loop of the alpha 2-Adrenergic Receptors Determines Subtype-specific Coupling to cAMP Production.

J. Nasman, C. C. Jansson, and K. E.O. Akerman (1997)
J. Biol. Chem. 272, 9703-9708
 |  Abstract »  |  Full Text »  |  PDF »

Novel "Restoration of Function" Mutagenesis Strategy to Identify Amino Acids of the delta -Opioid Receptor Involved in Ligand Binding.

M.-C. Pepin, S. Y. Yue, E. Roberts, C. Wahlestedt, and P. Walker (1997)
J. Biol. Chem. 272, 9260-9267
 |  Abstract »  |  Full Text »  |  PDF »

The Thrombin Receptor Second Cytoplasmic Loop Confers Coupling to Gq-like G Proteins in Chimeric Receptors. ADDITIONAL EVIDENCE FOR A COMMON TRANSMEMBRANE SIGNALING AND G PROTEIN COUPLING MECHANISM IN G PROTEIN-COUPLED RECEPTORS.

S. Verrall, M. Ishii, M. Chen, L. Wang, T. Tram, and S. R. Coughlin (1997)
J. Biol. Chem. 272, 6898-6902
 |  Abstract »  |  Full Text »  |  PDF »

Random Mutagenesis of the cAMP Chemoattractant Receptor, cAR1, of Dictyostelium. MUTANT CLASSES THAT CAUSE DISCRETE SHIFTS IN AGONIST AFFINITY AND LOCK THE RECEPTOR IN A NOVEL ACTIVATIONAL INTERMEDIATE.

J.-Y. Kim, M. J. Caterina, J. L.S. Milne, K. C. Lin, J. A. Borleis, and P. N. Devreotes (1997)
J. Biol. Chem. 272, 2060-2068
 |  Abstract »  |  Full Text »  |  PDF »

The Sixth Transmembrane Domains of the Human B1 and B2 Bradykinin Receptors Are Structurally Compatible and Involved in Discriminating between Subtype-selective Agonists.

T. Leeb, S. A. Mathis, and L. M.F. Leeb-Lundberg (1997)
J. Biol. Chem. 272, 311-317
 |  Abstract »  |  Full Text »  |  PDF »

Functional Interaction of Transmembrane Helices 3and 6in Rhodopsin. REPLACEMENT OF PHENYLALANINE 261BY ALANINE CAUSES REVERSION OF PHENOTYPE OF A GLYCINE 121REPLACEMENT MUTANT.

M. Han, S. W. Lin, M. Minkova, S. O. Smith, and T. P. Sakmar (1996)
J. Biol. Chem. 271, 32337-32342
 |  Abstract »  |  Full Text »  |  PDF »

A general method for determining helix packing in membrane proteins in situ: Helices I and II are close to helix VII in the lactose permease of Escherichia coli.

J. Wu and H. R. Kaback (1996)
PNAS 93, 14498-14502
 |  Abstract »  |  Full Text »  |  PDF »

Functional Role of the Third Cytoplasmic Loop in Muscarinic Receptor Dimerization.

R. Maggio, P. Barbier, F. Fornai, and G. U. Corsini (1996)
J. Biol. Chem. 271, 31055-31060
 |  Abstract »  |  Full Text »  |  PDF »

Transmembrane Regions V and VI of the Human Luteinizing Hormone Receptor Are Required for Constitutive Activation by a Mutation in the Third Intracellular Loop.

M. Kudo, Y. Osuga, B. K. Kobilka, and A. J.W. Hsueh (1996)
J. Biol. Chem. 271, 22470-22478
 |  Abstract »  |  Full Text »  |  PDF »

A Peptide Derived from a beta 2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation.

T. E. Hebert, S. Moffett, J.-P. Morello, T. P. Loisel, D. G. Bichet, C. Barret, and M. Bouvier (1996)
J. Biol. Chem. 271, 16384-16392
 |  Abstract »  |  Full Text »  |  PDF »

Chimeric Rat/Human Neurotensin Receptors Localize a Region of the Receptor Sensitive to Binding of a Novel, Species-specific, Picomolar Affinity Peptide.

B. Cusack, K. Groshan, D. J. McCormick, Y.-P. Pang, R. Perry, C.-T. Phung, T. Souder, and E. Richelson (1996)
J. Biol. Chem. 271, 15054-15059
 |  Abstract »  |  Full Text »  |  PDF »

Chimeric Mutagenesis of Putative G-protein Coupling Domains of the alpha 2A-Adrenergic Receptor. LOCALIZATION OF TWO REDUNDANT AND FULLY COMPETENT G.

M. G. Eason and S. B. Liggett (1996)
J. Biol. Chem. 271, 12826-12832
 |  Abstract »  |  Full Text »  |  PDF »

Structural Features of the Central Cannabinoid CB1 Receptor Involved in the Binding of the Specific CB1 Antagonist SR 141716A.

D. Shire, B. Calandra, M. Delpech, X. Dumont, M. Kaghad, Gér. Le Fur, D. Caput, and P. Ferrara (1996)
J. Biol. Chem. 271, 6941-6946
 |  Abstract »  |  Full Text »  |  PDF »

Mutagenic Analysis of Platelet Thromboxane Receptor Cysteines.

D. D. D'Angelo, J. J. Eubank, M. G. Davis, and G. W. Dorn II (1996)
J. Biol. Chem. 271, 6233-6240
 |  Abstract »  |  Full Text »  |  PDF »

Arrangement of Transmembrane Domains in Adrenergic Receptors.

T. Mizobe, M. Maze, V. Lam, S. Suryanarayana, and B. K. Kobilka (1996)
J. Biol. Chem. 271, 2387-2389
 |  Abstract »  |  Full Text »  |  PDF »

The Second Intracellular Loop of Metabotropic Glutamate Receptor 1 Cooperates with the Other Intracellular Domains to Control Coupling to G-proteins.

J. Gomeza, C. Joly, R. Kuhn, T. Knöpfel, J. Bockaert, and J.-P. Pin (1996)
J. Biol. Chem. 271, 2199-2205
 |  Abstract »  |  Full Text »  |  PDF »

Polar Residues in the Transmembrane Domains of the Type 1 Angiotensin II Receptor Are Required for Binding and Coupling.

C. Monnot, C. Bihoreau, S. Conchon, K. M. Curnow, P. Corvol, and E. Clauser (1996)
J. Biol. Chem. 271, 1507-1513
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular Domains of the Bradykinin B2 Receptor Involved in Ligand Binding and Agonist Sensing Defined by Anti-peptide Antibodies.

S. A. Alla, U. Quitterer, S. Grigoriev, A. Maidhof, M. Haasemann, K. Jarnagin, and W. Müller-Esterl (1996)
J. Biol. Chem. 271, 1748-1755
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a G(s) Coupling Domain in the Amino Terminus of the Third Intracellular Loop of the alpha[IMAGE]-Adrenergic Receptor.

M. G. Eason and S. B. Liggett (1995)
J. Biol. Chem. 270, 24753-24760
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Domains of the Human A(1) Adenosine Receptor That Are Important for Binding Receptor Subtype-selective Ligands Using Chimeric A(1)/A[IMAGE] Adenosine Receptors.

S. A. Rivkees, M. E. Lasbury, and H. Barbhaiya (1995)
J. Biol. Chem. 270, 20485-20490
 |  Abstract »  |  Full Text »  |  PDF »

Do Transmembrane Segments in Proteolyzed Sarcoplasmic Reticulum Ca[IMAGE]-ATPase Retain Their Functional Ca[IMAGE] Binding Properties after Removal of Cytoplasmic Fragments by Proteinase K?.

B. Juul, H. Turc, M. L. Durand, A. G. de Gracia, L. Denoroy, J. V. M, P. Champeil, and M. le Maire (1995)
J. Biol. Chem. 270, 20123-20134
 |  Abstract »  |  Full Text »  |  PDF »

Carboxyl-terminal Domains Determine Internalization and Recycling Characteristics of Bombesin Receptor Chimeras.

M.-J. Tseng, K. Detjen, V. Struk, and C. D. Logsdon (1995)
J. Biol. Chem. 270, 18858-18864
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Plasma Membrane Localization and Functional Rescue of Truncated Forms of a G Protein-coupled Receptor.

T. Schneberg, J. Liu, and J. Wess (1995)
J. Biol. Chem. 270, 18000-18006
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Identification of a Domain in the Angiotensin II Type 1 Receptor Determining G[IMAGE] Coupling by the Use of Receptor Chimeras.

C. Wang, S. Jayadev, and J. A. Escobedo (1995)
J. Biol. Chem. 270, 16677-16682
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A Chimeric Study of the Molecular Basis of Affinity and Selectivity of the [IMAGE] and the [IMAGE] Opioid Receptors.

F. Meng, M. T. Hoversten, R. C. Thompson, L. Taylor, S. J. Watson, and H. Akil (1995)
J. Biol. Chem. 270, 12730-12736
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Structural Basis of G Protein Specificity of Human Endothelin Receptors.

Y. Takagi, H. Ninomiya, A. Sakamoto, S. Miwa, and T. Masaki (1995)
J. Biol. Chem. 270, 10072-10078
 |  Abstract »  |  Full Text »  |  PDF »

Co-expressed Complementary Fragments of the Human Red Cell Anion Exchanger (Band 3, AE1) Generate Stilbene Disulfonate-sensitive Anion Transport.

J. D. Groves and M. J. A. Tanner (1995)
J. Biol. Chem. 270, 9097-9105
 |  Abstract »  |  Full Text »  |  PDF »

An Amino-terminal Variant of the Central Cannabinoid Receptor Resulting from Alternative Splicing.

D. Shire, C. Carillon, M. Kaghad, B. Calandra, M. Rinaldi-Carmona, Gér. Le Fur, D. Caput, and P. Ferrara (1995)
J. Biol. Chem. 270, 3726-3731
 |  Abstract »  |  Full Text »  |  PDF »

The Assembly and Organization of the alpha5 and alpha7 Helices from the Pore-forming Domain of Bacillusthuringiensis [IMAGE]-Endotoxin.

E. Gazit and Y. Shai (1995)
J. Biol. Chem. 270, 2571-2578
 |  Abstract »  |  Full Text »  |  PDF »

Allelic Variation in the D4 Dopamine Receptor (DRD4) Gene Does Not Predict Response to Clozapine.

P. A. Rao, D. Pickar, P. V. Gejman, A. Ram, E. S. Gershon, and J. Gelernter (1994)
Arch Gen Psychiatry 51, 912-917
 |  Abstract »  |  PDF »

G-Protein-linked Signaling Pathways Mediate Development in Dictyostelium.

R.L. Johnson, R. Gundersen, D. Hereld, G.S. Pitt, S. Tugendreich, C.L. Saxe, A.R. Kimmel, and P.N. Devreotes (1992)
Cold Spring Harb Symp Quant Biol 57, 169-176
 |  Abstract »  |  PDF »

Molecular Biology of Smell: Expression of the Multigene Family Encoding Putative Odorant Receptors.

A. Chess, L. Buck, M.M. Dowling, R. Axel, and J. Ngai (1992)
Cold Spring Harb Symp Quant Biol 57, 505-516
 |  Abstract »  |  PDF »

Molecular characterization of a functional cDNA encoding the rat substance P receptor.

A. Hershey and J. Krause (1990)
Science 247, 958-962
 |  Abstract »  |  PDF »

Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family.

K. McFarland, R Sprengel, H. Phillips, M Kohler, N Rosemblit, K Nikolics, D. Segaloff, and P. Seeburg (1989)
Science 245, 494-499
 |  Abstract »  |  PDF »

Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis.

B. Cunningham, P Jhurani, P Ng, and J. Wells (1989)
Science 243, 1330-1336
 |  Abstract »  |  PDF »

Analysis of ligand binding specificity of receptor chimeras.

W. Catterall (1989)
Science 243, 236-237
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Molecular Biology of Adrenergic Receptors.

R.J. Lefkowitz, B.K. Kobilka, J.L. Benovic, M. Bouvier, S. Cotecchia, W.P. Hausdorff, H.G. Dohlman, J.W. Regan, and M.G. Caron (1988)
Cold Spring Harb Symp Quant Biol 53, 507-514
 |  Abstract »  |  PDF »

From Membrane to Nucleus: The Pathway of Signal Transduction in Yeast and Its Genetic Control.

L. Marsh and I. Herskowitz (1988)
Cold Spring Harb Symp Quant Biol 53, 557-565
 |  Abstract »  |  PDF »

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