Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 13 May 1988:
Vol. 240. no. 4854, pp. 916 - 919
DOI: 10.1126/science.2834826
Prev | Table of Contents | Next

Articles

Science, Vol 240, Issue 4854, 916-919
Copyright © 1988 by American Association for the Advancement of Science

articles

HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes

JD Rosenblatt, AJ Cann, DJ Slamon, IS Smalberg, NP Shah, J Fujii, W Wachsman, and IS Chen

Department of Medicine, UCLA School of Medicine.

The human T-cell leukemia virus (HTLV) types I and II have two nonstructural genes that are encoded in overlapping reading frames. One of these genes, known as tax, has been shown to encode a protein responsible for enhanced transcription (transactivation) from the viral long terminal repeats (LTRs). Genetic evidence indicates that the second nonstructural gene of HTLV-II, here designated rex, acts in trans to modulate tax gene-mediated transactivation in a concentration-dependent fashion. The rex gene may regulate the process of transactivation during the viral life cycle.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Human T-Cell Leukemia Virus Type 1 Expressing Nonoverlapping Tax and Rex Genes Replicates and Immortalizes Primary Human T Lymphocytes but Fails To Replicate and Persist In Vivo.
I. Younis, B. Yamamoto, A. Phipps, and P. L. Green (2005)
J. Virol. 79, 14473-14481
   Abstract »    Full Text »    PDF »
Functional Domain Structure of Human T-Cell Leukemia Virus Type 2 Rex.
M. Narayan, I. Younis, D. M. D'Agostino, and P. L. Green (2003)
J. Virol. 77, 12829-12840
   Abstract »    Full Text »    PDF »
Phosphorylation of Two Serine Residues Regulates Human T-Cell Leukemia Virus Type 2 Rex Function.
M. Narayan, K. Kusuhara, and P. L. Green (2001)
J. Virol. 75, 8440-8448
   Abstract »    Full Text »    PDF »
Differences in the Ability of Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-2 Tax To Inhibit p53 Function.
R. Mahieux, C. A. Pise-Masison, P. F. Lambert, C. Nicot, L. De Marchis, A. Gessain, P. Green, W. Hall, and J. N. Brady (2000)
J. Virol. 74, 6866-6874
   Abstract »    Full Text »
Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements..
S M Hanly, L T Rimsky, M H Malim, J H Kim, J Hauber, M Duc Dodon, S Y Le, J V Maizel, B R Cullen, and W C Greene (1989)
Genes & Dev. 3, 1534-1544
   Abstract »    PDF »
Regulation of HIV and HTLV gene expression..
H Varmus (1988)
Genes & Dev. 2, 1055-1062
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)