Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 May 1988:
Vol. 240. no. 4853, pp. 760 - 767
DOI: 10.1126/science.3283937
Prev | Table of Contents | Next

Articles

Science, Vol 240, Issue 4853, 760-767
Copyright © 1988 by American Association for the Advancement of Science

articles

The design of molecular hosts, guests, and their complexes

DJ Cram

Department of Chemistry and Biochemistry, University of California, Los Angeles 90024.

The origins, definitions, tools, and guiding principles of host-guest chemistry are developed. Perching, nesting, and capsular complexes are exemplified through molecular model and crystal structure comparisons. The degree of preorganization of a host for binding is a central determinant of its binding power. Complementarity of binding site placement in host and guest is a central determinant of structural recognition in complexation. Examples are given of chiral recognition in complexation, of partial transacylase mimics, of caviplexes, and of a synthetic molecular cell.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Role of na+ and k+ in enzyme function..
M. J. Page and E. Di Cera (2006)
Physiol Rev 86, 1049-1092
   Abstract »    Full Text »    PDF »
A Structural Perspective on Enzymes Activated by Monovalent Cations.
E. Di Cera (2006)
J. Biol. Chem. 281, 1305-1308
   Abstract »    Full Text »    PDF »
Strategy to Discriminate between High and Low Affinity Bindings of Human Immunodeficiency Virus, Type 1 Integrase to Viral DNA.
L. Zargarian, M. S. Benleumi, J.-G. Renisio, H. Merad, R. G. Maroun, F. Wieber, O. Mauffret, H. Porumb, F. Troalen, and S. Fermandjian (2003)
J. Biol. Chem. 278, 19966-19973
   Abstract »    Full Text »    PDF »
Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors.
P. Lam, P. Jadhav, C. Eyermann, C. Hodge, Y Ru, L. Bacheler, J. Meek, M. Otto, M. Rayner, Y. Wong, et al. (1994)
Science 263, 380-384
   Abstract »    PDF »
Quantum Chemical Molecular Models for Fluorinated Polymers: Visualization of Structures and Vibrational Motions.
D. A. Dixon, W. B. Farnham, and P. J. Capobianco (1990)
International Journal of High Performance Computing Applications 4, 134-149
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)