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Science 22 April 1988:
Vol. 240. no. 4851, pp. 420 - 426
DOI: 10.1126/science.3358127
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Articles

Science, Vol 240, Issue 4851, 420-426
Copyright © 1988 by American Association for the Advancement of Science

articles

Stereoselective organic reactions: catalysts for carbonyl addition processes

DA Evans

Department of Chemistry, Harvard University, Cambridge, MA 02138.

Important advances are being made in the development of stereoselective organic reactions. Some of the emerging research directions that hold forth great promise in this area deal with the development of chiral catalysts for these processes. This review attempts to unify one aspect of this field, the development of catalysts and catalyst models for the enantioselective addition of hydride and carbon nucleophiles to carbonyl substrates. Mechanistic constructs for the stereodifferentiating transition states are provided.


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