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Science 15 April 1988:
Vol. 240. no. 4850, pp. 334 - 336
DOI: 10.1126/science.2832953
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Articles

Science, Vol 240, Issue 4850, 334-336
Copyright © 1988 by American Association for the Advancement of Science

articles

Exon-intron organization in genes of earthworm and vertebrate globins

SM Jhiang, Garey JR, and AF Riggs

Department of Zoology, University of Texas, Austin 78712.

The structure of an invertebrate, intron-containing globin gene has been determined as part of a study of the evolution of hemoglobin. The gene encoding chain c of Lumbricus terrestris hemoglobin has the two-intron, three-exon structure characteristic of vertebrate globin genes, and the exact positions of the splice junctions are conserved. The two introns interrupting the coding sequence are longer than those of known hemoglobins but shorter than myoglobin introns. The gene encodes a secretory preglobin containing a 16-residue signal peptide, as expected for an extracellular hemoglobin. However, no intron separates the DNA encoding the signal sequence from that of the globin sequence. The 3' untranslated region of the Lumbricus gene is much longer than those of the genes for other hemoglobins and is similar to those found for myoglobins.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Evolution of the Sulfide-Binding Function Within the Globin Multigenic Family of the Deep-Sea Hydrothermal Vent Tubeworm Riftia pachyptila.
X. Bailly, D. Jollivet, S. Vanin, J. Deutsch, F. Zal, F. Lallier, and A. Toulmond (2002)
Mol. Biol. Evol. 19, 1421-1433
   Abstract »    Full Text »    PDF »
Primer on Medical Genomics Part II: Background Principles and Methods in Molecular Genetics.
A. Tefferi, E. D. Wieben, G. W. Dewald, D. A. H. Whiteman, M. E. Bernard, and T. C. Spelsberg (2002)
Mayo Clin. Proc. 77, 785-808
   Abstract »    PDF »
Globin and Globin Gene Structure of the Nerve Myoglobin of Aphrodite aculeata.
S. Dewilde, M. Blaxter, M.-L. Van Hauwaert, J. Vanfleteren, E. L. Esmans, M. Marden, N. Griffon, and L. Moens (1996)
J. Biol. Chem. 271, 19865-19870
   Abstract »    Full Text »    PDF »


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