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Science 8 April 1988:
Vol. 240. no. 4849, pp. 213 - 215
DOI: 10.1126/science.2451291
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Articles

Science, Vol 240, Issue 4849, 213-215
Copyright © 1988 by American Association for the Advancement of Science

articles

Amiloride selectively blocks the low threshold (T) calcium channel

CM Tang, F Presser, and M Morad

University of Pennsylvania, Department of Physiology, Philadelphia 19104-6085.

More than one type of voltage-gated calcium channel has been identified in muscle cells and neurons. Many specific organic and inorganic blockers of the conventional, slowly inactivating high threshold (L) calcium channel have been reported. No specific blockers of the low threshold (T) channel have been as yet identified. Amiloride, a potassium sparing diuretic, has now been shown to selectively block the low threshold calcium channel in mouse neuroblastoma and chick dorsal root ganglion neurons. The selective blockade of the T-type calcium channel will allow identification of this channel in different tissues and characterization of its specific physiological role.


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