Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 1 April 1988:
Vol. 240. no. 4848, pp. 80 - 82
DOI: 10.1126/science.2832945

Articles

Science, Vol 240, Issue 4848, 80-82
Copyright © 1988 by American Association for the Advancement of Science


articles

Biologic features of HIV-1 that correlate with virulence in the host

C Cheng-Mayer, D Seto, M Tateno, and JA Levy

Department of Medicine, University of California, School of Medicine, San Francisco 94143.

Individuals infected with the human immunodeficiency virus type 1 (HIV-1) may be asymptomatic or have AIDS-related complex or the acquired immuno deficiency syndrome (AIDS). Little is known about the factors that influence progression of infection to AIDS. In this study of isolates of HIV-1 obtained at intervals during the infection of four individuals, the development of disease was found to be correlated with the emergence of HIV-1 variants that were more cytopathic in vitro as the disease progressed and that replicated more efficiently in a wide variety of different human cells. The biologic properties of HIV-1 in vitro thus appear to reflect its virulence in the host. Further studies of such sequentially isolated viruses may lead to the identification of viral genes that govern pathogenesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Different Tempo and Anatomic Location of Dual-Tropic and X4 Virus Emergence in a Model of R5 Simian-Human Immunodeficiency Virus Infection.
W. Ren, S. Tasca, K. Zhuang, A. Gettie, J. Blanchard, and C. Cheng-Mayer (2010)
J. Virol. 84, 340-351
   Abstract »    Full Text »    PDF »
R5X4 Viruses Are Evolutionary, Functional, and Antigenic Intermediates in the Pathway of a Simian-Human Immunodeficiency Virus Coreceptor Switch.
S. Tasca, S.-H. Ho, and C. Cheng-Mayer (2008)
J. Virol. 82, 7089-7099
   Abstract »    Full Text »    PDF »
Comparison of Plasma Viremia and Antibody Responses in Macaques Inoculated with Envelope Variants of Single-Cycle Simian Immunodeficiency Virus Differing in Infectivity and Cellular Tropism.
M. Q. DeGottardi, S. K. Lew, M. Piatak Jr., B. Jia, Y. Feng, S. J. Lee, J. M. Brenchley, D. C. Douek, T. Kodama, J. D. Lifson, et al. (2008)
J. Virol. 82, 321-334
   Abstract »    Full Text »    PDF »
FoxP3+ CD25+ CD8+ T-Cell Induction during Primary Simian Immunodeficiency Virus Infection in Cynomolgus Macaques Correlates with Low CD4+ T-Cell Activation and High Viral Load.
I. Karlsson, B. Malleret, P. Brochard, B. Delache, J. Calvo, R. Le Grand, and B. Vaslin (2007)
J. Virol. 81, 13444-13455
   Abstract »    Full Text »    PDF »
Dynamics of T-Cell Responses and Memory T Cells during Primary Simian Immunodeficiency Virus Infection in Cynomolgus Macaques.
I. Karlsson, B. Malleret, P. Brochard, B. Delache, J. Calvo, R. Le Grand, and B. Vaslin (2007)
J. Virol. 81, 13456-13468
   Abstract »    Full Text »    PDF »
Crystal Structure and Structural Mechanism of a Novel Anti-Human Immunodeficiency Virus and D-Amino Acid-Containing Chemokine.
D. Liu, N. Madani, Y. Li, R. Cao, W.-T. Choi, S. P. Kawatkar, M. Y. Lim, S. Kumar, C.-Z. Dong, J. Wang, et al. (2007)
J. Virol. 81, 11489-11498
   Abstract »    Full Text »    PDF »
Virally Induced CD4+ T Cell Depletion Is Not Sufficient to Induce AIDS in a Natural Host.
J. M. Milush, J. D. Reeves, S. N. Gordon, D. Zhou, A. Muthukumar, D. A. Kosub, E. Chacko, L. D. Giavedoni, C. C. Ibegbu, K. S. Cole, et al. (2007)
J. Immunol. 179, 3047-3056
   Abstract »    Full Text »    PDF »
Continued evolution of HIV-1 circulating in blood monocytes with antiretroviral therapy: genetic analysis of HIV-1 in monocytes and CD4+ T cells of patients with discontinued therapy..
N. Llewellyn, R. Zioni, H. Zhu, T. Andrus, Y. Xu, L. Corey, and T. Zhu (2006)
J. Leukoc. Biol. 80, 1118-1126
   Abstract »    Full Text »    PDF »
Differential HIV-1 replication in neonatal and adult blood mononuclear cells is influenced at the level of HIV-1 gene expression.
V. Sundaravaradan, S. K. Saxena, R. Ramakrishnan, V. R. K. Yedavalli, D. T. Harris, and N. Ahmad (2006)
PNAS 103, 11701-11706
   Abstract »    Full Text »    PDF »
Purifying selection of CCR5-tropic human immunodeficiency virus type 1 variants in AIDS subjects that have developed syncytium-inducing, CXCR4-tropic viruses..
G. Fernandez, A. Llano, M. Esgleas, B. Clotet, J. A. Este, and M. A. Martinez (2006)
J. Gen. Virol. 87, 1285-1294
   Abstract »    Full Text »    PDF »
HIV Pathogenesis: Knowledge Gained after Two Decades of Research.
J.A. Levy (2006)
Advances in Dental Research 19, 10-16
   Abstract »    Full Text »    PDF »
Evolution of Broad Host Range in Retroviruses Leads to Cell Death Mediated by Highly Cytopathic Variants.
G. J. A. Rainey and J. M. Coffin (2006)
J. Virol. 80, 562-570
   Abstract »    Full Text »    PDF »
Changes in Human Immunodeficiency Virus Type 1 Fitness and Genetic Diversity during Disease Progression.
R. M. Troyer, K. R. Collins, A. Abraha, E. Fraundorf, D. M. Moore, R. W. Krizan, Z. Toossi, R. L. Colebunders, M. A. Jensen, J. I. Mullins, et al. (2005)
J. Virol. 79, 9006-9018
   Abstract »    Full Text »    PDF »
Differential effects of R5 and X4 human immunodeficiency virus type 1 infection on CD4+ cell proliferation and activation.
C. P. Locher, S. A. Witt, R. Kassel, N. L. Dowell, S. Fujimura, and J. A. Levy (2005)
J. Gen. Virol. 86, 1171-1179
   Abstract »    Full Text »    PDF »
Cell-Type-Dependent Effect of Transforming Growth Factor {beta}, a Major Cytokine in Breast Milk, on Human Immunodeficiency Virus Type 1 Infection of Mammary Epithelial MCF-7 Cells or Macrophages.
M. Moriuchi and H. Moriuchi (2004)
J. Virol. 78, 13046-13052
   Abstract »    Full Text »    PDF »
Novel Host Range and Cytopathic Variant of Ecotropic Friend Murine Leukemia Virus.
Y. T. Jung, T. Wu, and C. A. Kozak (2004)
J. Virol. 78, 12189-12197
   Abstract »    Full Text »    PDF »
Compartmentalization of Human Immunodeficiency Virus Type 1 between Blood Monocytes and CD4+ T Cells during Infection.
J. A. Fulcher, Y. Hwangbo, R. Zioni, D. Nickle, X. Lin, L. Heath, J. I. Mullins, L. Corey, and T. Zhu (2004)
J. Virol. 78, 7883-7893
   Abstract »    Full Text »    PDF »
Where Does HIV Live?.
J. Stebbing, B. Gazzard, and D. C. Douek (2004)
N. Engl. J. Med. 350, 1872-1880
   Full Text »    PDF »
CD8+ T cell-mediated CXC chemokine receptor 4-simian/human immunodeficiency virus suppression in dually infected rhesus macaques.
J. M. Harouse, C. Buckner, A. Gettie, R. Fuller, R. Bohm, J. Blanchard, and C. Cheng-Mayer (2003)
PNAS 100, 10977-10982
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Resistance Is Associated with the Syncytium-Inducing Phenotype and Lower CD4 Cell Counts in Subtype CRF01_AE-Infected Patients.
V. R. Polonis, M. S. d. Souza, J. M. Darden, S. Chantakulkij, T. Chuenchitra, S. Nitayaphan, A. E. Brown, M. L. Robb, and D. L. Birx (2003)
J. Virol. 77, 8570-8576
   Abstract »    Full Text »    PDF »
Increased Mucosal Transmission but Not Enhanced Pathogenicity of the CCR5-Tropic, Simian AIDS-Inducing Simian/Human Immunodeficiency Virus SHIVSF162P3 Maps to Envelope gp120.
M. Hsu, J. M. Harouse, A. Gettie, C. Buckner, J. Blanchard, and C. Cheng-Mayer (2003)
J. Virol. 77, 989-998
   Abstract »    Full Text »    PDF »
Human Monoclonal Antibodies Specific for Conformation-Sensitive Epitopes of V3 Neutralize Human Immunodeficiency Virus Type 1 Primary Isolates from Various Clades.
M. K. Gorny, C. Williams, B. Volsky, K. Revesz, S. Cohen, V. R. Polonis, W. J. Honnen, S. C. Kayman, C. Krachmarov, A. Pinter, et al. (2002)
J. Virol. 76, 9035-9045
   Abstract »    Full Text »    PDF »
Compartmentalization of Surface Envelope Glycoprotein of Human Immunodeficiency Virus Type 1 during Acute and Chronic Infection.
L. Zhang, L. Rowe, T. He, C. Chung, J. Yu, W. Yu, A. Talal, M. Markowitz, and D. D. Ho (2002)
J. Virol. 76, 9465-9473
   Abstract »    Full Text »    PDF »
Transepithelial transport of HIV-1 by M cells is receptor-mediated.
G. Fotopoulos, A. Harari, P. Michetti, D. Trono, G. Pantaleo, and J.-P. Kraehenbuhl (2002)
PNAS 99, 9410-9414
   Abstract »    Full Text »    PDF »
Highly Pathogenic Simian Immunodeficiency Virus mne Variants That Emerge during the Course of Infection Evolve Enhanced Infectivity and the Ability To Downregulate CD4 but Not Class I Major Histocompatibility Complex Antigens.
P. G. Patel, M. T. Yu Kimata, J. E. Biggins, J. M. Wilson, and J. T. Kimata (2002)
J. Virol. 76, 6425-6434
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Type 1 Neutralization Measured by Flow Cytometric Quantitation of Single-Round Infection of Primary Human T Cells.
J. R. Mascola, M. K. Louder, C. Winter, R. Prabhakara, S. C. De Rosa, D. C. Douek, B. J. Hill, D. Gabuzda, and M. Roederer (2002)
J. Virol. 76, 4810-4821
   Abstract »    Full Text »    PDF »
Contribution of Peaks of Virus Load to Simian Immunodeficiency Virus Pathogenesis.
R. R. Regoes, S. I. Staprans, M. B. Feinberg, and S. Bonhoeffer (2002)
J. Virol. 76, 2573-2578
   Abstract »    Full Text »    PDF »
Identification of Shared Populations of Human Immunodeficiency Virus Type 1 Infecting Microglia and Tissue Macrophages outside the Central Nervous System.
T. H. Wang, Y. K. Donaldson, R. P. Brettle, J. E. Bell, and P. Simmonds (2001)
J. Virol. 75, 11686-11699
   Abstract »    Full Text »    PDF »
No Selection for CCR5 Coreceptor Usage during Parenteral Transmission of Macrophagetropic Syncytium-Inducing Human Immunodeficiency Virus Type 1.
F. A. Koning, D. Schols, and H. Schuitemaker (2001)
J. Virol. 75, 8848-8853
   Abstract »    Full Text »    PDF »
The pathogenesis of HIV-1 infection.
J. Weber (2001)
Br. Med. Bull. 58, 61-72
   Abstract »    Full Text »    PDF »
Antigenic Variation within the CD4 Binding Site of Human Immunodeficiency Virus Type 1 gp120: Effects on Chemokine Receptor Utilization.
A. L. Hammond, J. Lewis, J. May, J. Albert, P. Balfe, and J. A. McKeating (2001)
J. Virol. 75, 5593-5603
   Abstract »    Full Text »    PDF »
Membrane-Fusing Capacity of the Human Immunodeficiency Virus Envelope Proteins Determines the Efficiency of CD4+ T-Cell Depletion in Macaques Infected by a Simian-Human Immunodeficiency Virus.
B. Etemad-Moghadam, D. Rhone, T. Steenbeke, Y. Sun, J. Manola, R. Gelman, J. W. Fanton, P. Racz, K. Tenner-Racz, M. K. Axthelm, et al. (2001)
J. Virol. 75, 5646-5655
   Abstract »    Full Text »    PDF »
Naturally Occurring Deletional Mutation in the C-Terminal Cytoplasmic Tail of CCR5 Affects Surface Trafficking of CCR5.
T. Shioda, E. E. Nakayama, Y. Tanaka, X. Xin, H. Liu, A. Kawana-Tachikawa, A. Kato, Y. Sakai, Y. Nagai, and A. Iwamoto (2001)
J. Virol. 75, 3462-3468
   Abstract »    Full Text »    PDF »
Positive and Negative Aspects of the Human Immunodeficiency Virus Protease: Development of Inhibitors versus Its Role in AIDS Pathogenesis.
K. Ikuta, S. Suzuki, H. Horikoshi, T. Mukai, and R. B. Luftig (2000)
Microbiol. Mol. Biol. Rev. 64, 725-745
   Abstract »    Full Text »    PDF »
Mono Mac 1: a new in vitro model system to study HIV-1 infection in human cells of the mononuclear phagocyte series.
N. Genois, G. A Robichaud, and M. J. Tremblay (2000)
J. Leukoc. Biol. 68, 854-864
   Abstract »    Full Text »
T-tropic human immunodeficiency virus (HIV) type 1 Nef protein enters human monocyte-macrophages and induces resistance to HIV replication: a possible mechanism of HIV T-tropic emergence in AIDS.
L. Alessandrini, A. C. Santarcangelo, E. Olivetta, F. Ferrantelli, P. d’Aloja, K. Pugliese, E. Pelosi, C. Chelucci, G. Mattia, C. Peschle, et al. (2000)
J. Gen. Virol. 81, 2905-2917
   Abstract »    Full Text »
Interferon gamma and interleukin 6 modulate the susceptibility of macrophages to human immunodeficiency virus type 1 infection.
M. Zaitseva, S. Lee, C. Lapham, R. Taffs, L. King, T. Romantseva, J. Manischewitz, and H. Golding (2000)
Blood 96, 3109-3117
   Abstract »    Full Text »    PDF »
V2 Loop Glycosylation of the Human Immunodeficiency Virus Type 1 SF162 Envelope Facilitates Interaction of This Protein with CD4 and CCR5 Receptors and Protects the Virus from Neutralization by Anti-V3 Loop and Anti-CD4 Binding Site Antibodies.
A. Ly and L. Stamatatos (2000)
J. Virol. 74, 6769-6776
   Abstract »    Full Text »    PDF »
Polymorphism in the Interleukin-4 Promoter Affects Acquisition of Human Immunodeficiency Virus Type 1 Syncytium-Inducing Phenotype.
E. E. Nakayama, Y. Hoshino, X. Xin, H. Liu, M. Goto, N. Watanabe, H. Taguchi, A. Hitani, A. Kawana-Tachikawa, M. Fukushima, et al. (2000)
J. Virol. 74, 5452-5459
   Abstract »    Full Text »    PDF »
Envelope Glycoprotein Determinants of Increased Fusogenicity in a Pathogenic Simian-Human Immunodeficiency Virus (SHIV-KB9) Passaged In Vivo.
B. Etemad-Moghadam, Y. Sun, E. K. Nicholson, M. Fernandes, K. Liou, R. Gomila, J. Lee, and J. Sodroski (2000)
J. Virol. 74, 4433-4440
   Abstract »    Full Text »    PDF »
Pathogenesis of Primary R5 Human Immunodeficiency Virus Type 1 Clones in SCID-hu Mice.
R. M. Scoggins, J. R. Taylor Jr., J. Patrie, A. B. van't Wout, H. Schuitemaker, and D. Camerini (2000)
J. Virol. 74, 3205-3216
   Abstract »    Full Text »    PDF »
Involvement of both the V2 and V3 Regions of the CCR5-Tropic Human Immunodeficiency Virus Type 1 Envelope in Reduced Sensitivity to Macrophage Inflammatory Protein 1alpha.
Y. Maeda, M. Foda, S. Matsushita, and S. Harada (2000)
J. Virol. 74, 1787-1793
   Abstract »    Full Text »    PDF »
Limited expression of R5-tropic HIV-1 in CCR5-positive type 1-polarized T cells explained by their ability to produce RANTES, MIP-1alpha , and MIP-1beta.
F. Annunziato, G. Galli, F. Nappi, L. Cosmi, R. Manetti, E. Maggi, B. Ensoli, and S. Romagnani (2000)
Blood 95, 1167-1174
   Abstract »    Full Text »    PDF »
Broadening of coreceptor usage by human immunodeficiency virus type 2 does not correlate with increased pathogenicity in an in vivo model.
M. E. van der Ende, C. Guillon, P. H. M. Boers, R. A. Gruters, P. Racz, K. Tenner-Racz, A. D. M. E. Osterhaus, and M. Schutten (2000)
J. Gen. Virol. 81, 507-513
   Abstract »    Full Text »
Mosaic Structure of the Human Immunodeficiency Virus Type 1 Genome Infecting Lymphoid Cells and the Brain: Evidence for Frequent In Vivo Recombination Events in the Evolution of Regional Populations.
A. Morris, M. Marsden, K. Halcrow, E. S. Hughes, R. P. Brettle, J. E. Bell, and P. Simmonds (1999)
J. Virol. 73, 8720-8731
   Abstract »    Full Text »    PDF »
Inhibitory Mechanism of the CXCR4 Antagonist T22 against Human Immunodeficiency Virus Type 1 Infection.
T. Murakami, T.-Y. Zhang, Y. Koyanagi, Y. Tanaka, J. Kim, Y. Suzuki, S. Minoguchi, H. Tamamura, M. Waki, A. Matsumoto, et al. (1999)
J. Virol. 73, 7489-7496
   Abstract »    Full Text »    PDF »
Characterization of V3 Sequence Heterogeneity in Subtype C Human Immunodeficiency Virus Type 1 Isolates from Malawi: Underrepresentation of X4 Variants.
L.-H. Ping, J. A. E. Nelson, I. F. Hoffman, J. Schock, S. L. Lamers, M. Goodman, P. Vernazza, P. Kazembe, M. Maida, D. Zimba, et al. (1999)
J. Virol. 73, 6271-6281
   Abstract »    Full Text »    PDF »
Induction of MHC Class I Expression on Immature Thymocytes in HIV-1-Infected SCID-hu Thy/Liv Mice: Evidence of Indirect Mechanisms.
G. Kovalev, K. Duus, L. Wang, R. Lee, M. Bonyhadi, D. Ho, J. M. McCune, H. Kaneshima, and L. Su (1999)
J. Immunol. 162, 7555-7562
   Abstract »    Full Text »    PDF »
Polymorphism in chemokine promoter affects HIV-1 disease progression.
H. Liu, D. Chao, E. E. Nakayama, H. Taguchi, M. Goto, X. Xin, J.-k. Takamatsu, H. Saito, Y. Ishikawa, T. Akaza, et al. (1999)
PNAS 96, 4581-4585
   Abstract »    Full Text »    PDF »
Differential Cell Tropism of Feline Immunodeficiency Virus Molecular Clones In Vivo.
G. A. Dean, S. Himathongkham, and E. E. Sparger (1999)
J. Virol. 73, 2596-2603
   Abstract »    Full Text »    PDF »
Comparison of Immunity Generated by Nucleic Acid-, MF59-, and ISCOM-Formulated Human Immunodeficiency Virus Type 1 Vaccines in Rhesus Macaques: Evidence for Viral Clearance.
E. J. Verschoor, P. Mooij, H. Oostermeijer, M. van der Kolk, P. ten Haaft, B. Verstrepen, Y. Sun, B. Morein, L. Akerblom, D. H. Fuller, et al. (1999)
J. Virol. 73, 3292-3300
   Abstract »    Full Text »    PDF »
Distinct Human Immunodeficiency Virus Strains in the Bone Marrow Are Associated with the Development of Thrombocytopenia.
F. Voulgaropoulou, B. Tan, M. Soares, B. Hahn, and L. Ratner (1999)
J. Virol. 73, 3497-3504
   Abstract »    Full Text »    PDF »
Differential Effects of Human Immunodeficiency Virus Isolates on beta -Chemokine and Gamma Interferon Production and on Cell Proliferation.
G. Greco, S. H. Fujimura, D. V. Mourich, and J. A. Levy (1999)
J. Virol. 73, 1528-1534
   Abstract »    Full Text »    PDF »
Coreceptor Specificity of Temporal Variants of Simian Immunodeficiency Virus Mne.
J. T. Kimata, J. J. Gosink, V. N. KewalRamani, L. M. Rudensey, D. R. Littman, and J. Overbaugh (1999)
J. Virol. 73, 1655-1660
   Abstract »    Full Text »    PDF »
Determinant in Human Immunodeficiency Virus Type 1 for Efficient Replication under Cytokine-Induced CD4+ T-Helper 1 (Th1)- and Th2-Type Conditions.
Y. Suzuki, Y. Koyanagi, Y. Tanaka, T. Murakami, N. Misawa, N. Maeda, T. Kimura, H. Shida, J. A. Hoxie, W. A. O'Brien, et al. (1999)
J. Virol. 73, 316-324
   Abstract »    Full Text »    PDF »
Level of ICAM-1 Surface Expression on Virus Producer Cells Influences both the Amount of Virion-Bound Host ICAM-1 and Human Immunodeficiency Virus Type 1 Infectivity.
J.-S. Paquette, J.-F. Fortin, L. Blanchard, and M. J. Tremblay (1998)
J. Virol. 72, 9329-9336
   Abstract »    Full Text »    PDF »
Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands.
L. A. Dickinson, R. J. Gulizia, J. W. Trauger, E. E. Baird, D. E. Mosier, J. M. Gottesfeld, and P. B. Dervan (1998)
PNAS 95, 12890-12895
   Abstract »    Full Text »    PDF »
Mortality among Human Immunodeficiency Virus Type 2-Positive Villagers in Rural Guinea-Bissau Is Correlated with Viral Genotype.
N. C. Grassly, Z. Xiang, K. Ariyoshi, P. Aaby, H. Jensen, M. Schim van der Loeff, F. Dias, H. Whittle, and J. Breuer (1998)
J. Virol. 72, 7895-7899
   Abstract »    Full Text »    PDF »
Characterization of Simian-Human Immunodeficiency Virus Envelope Glycoprotein Epitopes Recognized by Neutralizing Antibodies from Infected Monkeys.
B. Etemad-Moghadam, G. B. Karlsson, M. Halloran, Y. Sun, D. Schenten, M. Fernandes, N. L. Letvin, and J. Sodroski (1998)
J. Virol. 72, 8437-8445
   Abstract »    Full Text »    PDF »
Cutting Edge: Cytokines Regulate Expression and Function of the HIV Coreceptor CXCR4 on Human Mature Dendritic Cells.
J. P. Zoeteweij, H. Golding, H. Mostowski, and A. Blauvelt (1998)
J. Immunol. 161, 3219-3223
   Abstract »    Full Text »    PDF »
CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4+ T Cells: Role of signal transduction.
A. Kinter, A. Catanzaro, J. Monaco, M. Ruiz, J. Justement, S. Moir, J. Arthos, A. Oliva, L. Ehler, S. Mizell, et al. (1998)
PNAS 95, 11880-11885
   Abstract »    Full Text »    PDF »
beta -Chemokines and neutralizing antibody titers correlate with sterilizing immunity generated in HIV-1 vaccinated macaques.
J. L. Heeney, V. J. P. Teeuwsen, M. van Gils, W. M. J. M. Bogers, C. D. G. Morghen, A. Radaelli, S. Barnett, B. Morein, L. Akerblom, Y. Wang, et al. (1998)
PNAS 95, 10803-10808
   Abstract »    Full Text »    PDF »
Viral Genetic Evolution in Macaques Infected with Molecularly Cloned Simian Immunodeficiency Virus Correlates with the Extent of Persistent Viremia.
V. M. Hirsch, G. Dapolito, A. Hahn, J. Lifson, D. Montefiori, C. R. Brown, and R. Goeken (1998)
J. Virol. 72, 6482-6489
   Abstract »    Full Text »    PDF »
Human Immunodeficiency Virus Type 1 T-Lymphotropic Strains Enter Macrophages via a CD4- and CXCR4-Mediated Pathway: Replication Is Restricted at a Postentry Level.
H. Schmidtmayerova, M. Alfano, G. Nuovo, and M. Bukrinsky (1998)
J. Virol. 72, 4633-4642
   Abstract »    Full Text »    PDF »
Evolution of Syncytium-Inducing and Non-Syncytium-Inducing Biological Virus Clones in Relation to Replication Kinetics during the Course of Human Immunodeficiency Virus Type 1 Infection.
A. B. van 't Wout, H. Blaak, L. J. Ran, M. Brouwer, C. Kuiken, and H. Schuitemaker (1998)
J. Virol. 72, 5099-5107
   Abstract »    Full Text »    PDF »
Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1alpha (SDF-1alpha ) and SDF-1beta are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage.
T. Shioda, H. Kato, Y. Ohnishi, K. Tashiro, M. Ikegawa, E. E. Nakayama, H. Hu, A. Kato, Y. Sakai, H. Liu, et al. (1998)
PNAS 95, 6331-6336
   Abstract »    Full Text »    PDF »
Factors Secreted by Human T Lymphotropic Virus Type I (HTLV-I)-infected Cells Can Enhance or Inhibit Replication of HIV-1 in HTLV-I-uninfected Cells: Implications for In Vivo Coinfection with HTLV-I and HIV-1.
H. Moriuchi, M. Moriuchi, and A. S. Fauci (1998)
J. Exp. Med. 187, 1689-1697
   Abstract »    Full Text »    PDF »
Disturbed CD4+ T Cell Homeostasis and In Vitro HIV-1 Susceptibility in Transgenic Mice Expressing T Cell Line-tropic HIV-1 Receptors.
S. Sawada, K. Gowrishankar, R. Kitamura, M. Suzuki, G. Suzuki, S. Tahara, and A. Koito (1998)
J. Exp. Med. 187, 1439-1449
   Abstract »    Full Text »    PDF »
In Vivo Evolution of a Novel, Syncytium-Inducing and Cytopathic Feline Leukemia Virus Variant.
J. L. Rohn, M. S. Moser, S. R. Gwynn, D. N. Baldwin, and J. Overbaugh (1998)
J. Virol. 72, 2686-2696
   Abstract »    Full Text »    PDF »
The Cell Tropism of Human Immunodeficiency Virus Type 1 Determines the Kinetics of Plasma Viremia in SCID Mice Reconstituted with Human Peripheral Blood Leukocytes.
G. R. Picchio, R. J. Gulizia, K. Wehrly, B. Chesebro, and D. E. Mosier (1998)
J. Virol. 72, 2002-2009
   Abstract »    Full Text »    PDF »
Use of Murine CXCR-4 as a Second Receptor by Some T-Cell-Tropic Human Immunodeficiency Viruses.
C. Parolin, A. Borsetti, H. Choe, M. Farzan, P. Kolchinsky, M. Heesen, Q. Ma, C. Gerard, G. Palu, M. E. Dorf, et al. (1998)
J. Virol. 72, 1652-1656
   Abstract »    Full Text »    PDF »
A Lymph Node-Derived Cytopathic Simian Immunodeficiency Virus Mne Variant Replicates in Nonstimulated Peripheral Blood Mononuclear Cells.
J. T. Kimata, A. Mozaffarian, and J. Overbaugh (1998)
J. Virol. 72, 245-256
   Abstract »    Full Text »    PDF »
Analysis of the Temporal Relationship between Human Immunodeficiency Virus Type 1 Quasispecies in Sequential Blood Samples and Various Organs Obtained at Autopsy.
A. B. van't Wout, L. J. Ran, C. L. Kuiken, N. A. Kootstra, S. T. Pals, and H. Schuitemaker (1998)
J. Virol. 72, 488-496
   Abstract »    Full Text »    PDF »
Is the clinical course of HIV-1 changing? Cohort study.
A Sinicco, R Fora, R Raiteri, M Sciandra, G Bechis, M M Calvo, and P Gioannini (1997)
BMJ 314, 1232
   Abstract »    Full Text »
Change in Coreceptor Use Correlates with Disease Progression in HIV-1-Infected Individuals.
R. I. Connor, K. E. Sheridan, D. Ceradini, S. Choe, and N. R. Landau (1997)
J. Exp. Med. 185, 621-628
   Abstract »    Full Text »    PDF »
Sensitivity to inhibition by beta -chemokines correlates with biological phenotypes of primary HIV-1 isolates.
M. Jansson, M. Popovic, A. Karlsson, F. Cocchi, P. Rossi, J. Albert, and H. Wigzell (1996)
PNAS 93, 15382-15387
   Abstract »    Full Text »    PDF »
The Emerging Genetic Diversity of HIV: The Importance of Global Surveillance for Diagnostics, Research, and Prevention.
D. J. Hu, T. J. Dondero, M. A. Rayfield, J. R. George, G. Schochetman, H. W. Jaffe, C.-C. Luo, M. L. Kalish, B. G. Weniger, C.-P. Pau, et al. (1996)
JAMA 275, 210-216
   Abstract »    PDF »
HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy.
J. Coffin (1995)
Science 267, 483-489
   Abstract »    PDF »
Features of HIV-1 That Could Influence Maternal-Child Transmission.
S. C. Kliks, D. W. Wara, D. V. Landers, and J. A. Levy (1994)
JAMA 272, 467-474
   Abstract »    PDF »
Participation of HIV-Infected Patients in Autologous Blood Programs.
P. D. Mintz (1993)
JAMA 269, 2892-2894
   Abstract »    PDF »
Relation of phenotype evolution of HIV-1 to envelope V2 configuration.
M Groenink, R. Fouchier, S Broersen, C. Baker, M Koot, A. van't Wout, H. Huisman, F Miedema, M Tersmette, and H Schuitemaker (1993)
Science 260, 1513-1516
   Abstract »    PDF »
Rapid loss of CD4+ T cells in human-PBL-SCID mice by noncytopathic HIV isolates.
D. Mosier, R. Gulizia, P. MacIsaac, B. Torbett, and J. Levy (1993)
Science 260, 689-692
   Abstract »    PDF »
HIV-induced syncytia of a T cell line form single giant pseudopods and are motile.
A Sylwester, D Wessels, S. Anderson, R. Warren, D. Shutt, R. Kennedy, and D. Soll (1993)
J. Cell Sci. 106, 941-953
   Abstract »    PDF »
Identification of envelope V3 loop as the major determinant of CD4 neutralization sensitivity of HIV-1.
S. Hwang, T. Boyle, H. Lyerly, and B. Cullen (1992)
Science 257, 535-537
   Abstract »    PDF »
Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.
S. Hwang, T. Boyle, H. Lyerly, and B. Cullen (1991)
Science 253, 71-74
   Abstract »    PDF »
Differential effects of nef on HIV replication: implications for viral pathogenesis in the host.
C Cheng-Mayer, P Iannello, K Shaw, P. Luciw, and J. Levy (1989)
Science 246, 1629-1632
   Abstract »    PDF »
The Acquired Immunodeficiency Syndrome (AIDS) Dementia Complex.
D. D. Ho, D. E. Bredesen, H. V. Vinters, and E. S. Daar (1989)
Ann Intern Med 111, 400-410
   Abstract »    PDF »
Human Immunodeficiency Viruses and the Pathogenesis of AIDS.
J. A. Levy (1989)
JAMA 261, 2997-3006
   Abstract »    PDF »
Biomedical and Social Aspects of Pediatric AIDS.
P. R. Dokecki, A. A. Baumeister, and F. D. Kupstas (1989)
Journal of Early Intervention 13, 99-113
   Abstract »    PDF »
Characterization of a noncytopathic HIV-2 strain with unusual effects on CD4 expression.
L. Evans, J Moreau, K Odehouri, H Legg, A Barboza, C Cheng-Mayer, and J. Levy (1988)
Science 240, 1522-1525
   Abstract »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)