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Science 18 March 1988:
Vol. 239. no. 4846, pp. 1418 - 1420
DOI: 10.1126/science.2450401
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Articles

Science, Vol 239, Issue 4846, 1418-1420
Copyright © 1988 by American Association for the Advancement of Science

articles

Duchenne muscular dystrophy gene expression in normal and diseased human muscle

MO Scott, JE Sylvester, T Heiman-Patterson, YJ Shi, W Fieles, H Stedman, A Burghes, P Ray, R Worton, and KH Fischbeck

Neurology Department, Hospital of the University of Pennsylvania, Philadelphia, 19104.

A probe for the 5' end of the Duchenne muscular dystrophy (DMD) gene was used to study expression of the gene in normal human muscle, myogenic cell cultures, and muscle from patients with DMD. Expression was found in RNA from normal fetal muscle, adult cardiac and skeletal muscle, and cultured muscle after myoblast fusion. In DMD muscle, expression of this portion of the gene was also revealed by in situ RNA hybridization, particularly in regenerating muscle fibers.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Review Article: Dystrophin-Related Muscular Dystrophies.
J.A. Witkowski (1989)
J Child Neurol 4, 251-271
   Abstract »    PDF »
The Molecular Genetic Revolution: Its Impact on Clinical Neurology.
C. S. Payne and A. D. Roses (1988)
Arch Neurol 45, 1366-1376
   Abstract »    PDF »


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