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Science 18 March 1988: Vol. 239. no. 4846, pp. 1400 - 1405 DOI: 10.1126/science.2831625
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Articles
Science, Vol 239, Issue 4846, 1400-1405
Copyright © 1988 by American Association for the Advancement of Science
Activation of cell-specific expression of rat growth hormone and prolactin genes by a common transcription factor
C Nelson,
VR Albert,
HP Elsholtz,
LI Lu,
and
MG Rosenfeld
Eukaryotic Regulatory Biology Program, University of California, San Diego, School of Medicine 92093.
In the anterior pituitary gland, there are five phenotypically distinct cell types, including cells that produce either prolactin (lactotrophs) or growth hormone (somatotrophs). Multiple, related cis-active elements that exhibit synergistic interactions appear to be the critical determinants of the transcriptional activation of the rat prolactin and growth hormone genes. A common positive tissue-specific transcription factor, referred to as Pit-1, appears to bind to all the cell-specific elements in each gene and to be required for the activation of both the prolactin and growth hormone genes. The data suggest that, in the course of development, a single tissue-specific factor activates sets of genes that ultimately exhibit restricted cell-specific expression and define cellular phenotype.
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| Abstract »
| Full Text »
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| Abstract »
| Full Text »
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- T. Schlake, M. Schorpp, M. Nehls, and T. Boehm (1997)
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| Abstract »
| Full Text »
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- M. Delhase, J.-L. Castrillo, M. de la Hoya, F. Rajas, and E. L. Hooghe-Peters (1996)
J. Biol. Chem.
271, 32349-32358
| Abstract »
| Full Text »
| PDF »
- Overgrowth.
- J. F. Sotos (1996)
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35, 577-590
| PDF »
- Thyroid Hormone Receptor beta 2 Promoter Activity in Pituitary Cells Is Regulated by Pit-1.
- W. M. Wood, J. M. Dowding, T. M. Bright, M. T. McDermott, B. R. Haugen, D. F. Gordon, and E. C. Ridgway (1996)
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271, 24213-24220
| Abstract »
| Full Text »
| PDF »
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- T. Iwasaki, M. Yamada, T. Satoh, S. Konaka, Y. Ren, K. Hashimoto, H. Kohga, Y. Kato, and M. Mori (1996)
J. Biol. Chem.
271, 22183-22188
| Abstract »
| Full Text »
| PDF »
- Regulation of Human Involucrin Promoter Activity by POU Domain Proteins.
- J. F. Welter, H. Gali, J. F. Crish, and R. L. Eckert (1996)
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271, 14727-14733
| Abstract »
| Full Text »
| PDF »
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- S Nakai, H Kawano, T Yudate, M Nishi, J Kuno, A Nagata, K Jishage, H Hamada, H Fujii, and K Kawamura (1995)
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9, 3109-3121
| Abstract »
| PDF »
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- J. Gillespie-Brown, S. J. Fuller, M. A. Bogoyevitch, S. Cowley, and P. H. Sugden (1995)
J. Biol. Chem.
270, 28092-28096
| Abstract »
| Full Text »
| PDF »
- In Vivo Mutational Analysis of the DNA Binding Domain of the Tissue-specific Transcription Factor, Pit-1.
- J. Liang, S. Moye-Rowley, and R. A. Maurer (1995)
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270, 25520-25525
| Abstract »
| Full Text »
| PDF »
- A Composite Ets/Pit-1 Binding Site in the Prolactin Gene Can Mediate Transcriptional Responses to Multiple Signal Transduction Pathways.
- P. W. Howard and R. A. Maurer (1995)
J. Biol. Chem.
270, 20930-20936
| Abstract »
| Full Text »
| PDF »
- Pit-1 binding to specific DNA sites as a monomer or dimer determines gene-specific use of a tyrosine-dependent synergy domain..
- J M Holloway, D P Szeto, K M Scully, C K Glass, and M G Rosenfeld (1995)
Genes & Dev.
9, 1992-2006
| Abstract »
| PDF »
- The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain..
- W Herr and M A Cleary (1995)
Genes & Dev.
9, 1679-1693
| PDF »
- A Dopamine-responsive Domain in the N-terminal Sequence of Pit-1.
- A. M. Lew and H. P. Elsholtz (1995)
J. Biol. Chem.
270, 7156-7160
| Abstract »
| Full Text »
| PDF »
- Pit-1 Exhibits a Unique Promoter Spacing Requirement for Activation and Synergism.
- K. P. Smith, B. Liu, C. Scott, and Z. D. Sharp (1995)
J. Biol. Chem.
270, 4484-4491
| Abstract »
| Full Text »
| PDF »
- Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression..
- S M Lipkin, A M Naar, K A Kalla, R A Sack, and M G Rosenfeld (1993)
Genes & Dev.
7, 1674-1687
| Abstract »
| PDF »
- A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene..
- S J Rhodes, R Chen, G E DiMattia, K M Scully, K A Kalla, S C Lin, V C Yu, and M G Rosenfeld (1993)
Genes & Dev.
7, 913-932
| Abstract »
| PDF »
- GHF-1-promoter-targeted immortalization of a somatotropic progenitor cell results in dwarfism in transgenic mice..
- D Lew, H Brady, K Klausing, K Yaginuma, L E Theill, C Stauber, M Karin, and P L Mellon (1993)
Genes & Dev.
7, 683-693
| Abstract »
| PDF »
- Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex..
- M S German, J Wang, R B Chadwick, and W J Rutter (1992)
Genes & Dev.
6, 2165-2176
| Abstract »
| PDF »
- A Mutation in the POU-Homeodomain of Pit-1 Responsible for Combined Pituitary Hormone Deficiency.
- S. Radovick, M. Nations, Y. Du, L. A. Berg, B. D. Weintraub, and F. E. Wondisford (1992)
Science
257, 1115-1118
| Abstract »
| PDF »
- Mutation of the POU-Specific Domain of Pit-1 and Hypopituitarism Without Pituitary Hypoplasia.
- R. W. Pfaffle, G. E. DiMattia, J. S. Parks, M. R. Brown, J. M. Wit, M. Jansen, H. Van der Nat, J. L. Van den Brande, M. G. Rosenfeld, and H. A. Ingraham (1992)
Science
257, 1118-1121
| Abstract »
| PDF »
- TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins..
- D W Drolet, K M Scully, D M Simmons, M Wegner, K T Chu, L W Swanson, and M G Rosenfeld (1991)
Genes & Dev.
5, 1739-1753
| Abstract »
| PDF »
- Variable effects of phosphorylation of Pit-1 dictated by the DNA response elements.
- M. Kapiloff, Y Farkash, M Wegner, and M. Rosenfeld (1991)
Science
253, 786-789
| Abstract »
| PDF »
- The pituitary-specific regulatory gene GHF1 contains a minimal cell type-specific promoter centered around its TATA box..
- A McCormick, H Brady, J Fukushima, and M Karin (1991)
Genes & Dev.
5, 1490-1503
| Abstract »
| PDF »
- POU-domain proteins Pit-1 and Oct-1 interact to form a heteromeric complex and can cooperate to induce expression of the prolactin promoter..
- J W Voss, L Wilson, and M G Rosenfeld (1991)
Genes & Dev.
5, 1309-1320
| Abstract »
| PDF »
- POU-domain transcription factors: pou-er-ful developmental regulators..
- M G Rosenfeld (1991)
Genes & Dev.
5, 897-907
| PDF »
- Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells..
- P A Ney, B P Sorrentino, K T McDonagh, and A W Nienhuis (1990)
Genes & Dev.
4, 993-1006
| Abstract »
| PDF »
- Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs..
- C Nelson, L P Shen, A Meister, E Fodor, and W J Rutter (1990)
Genes & Dev.
4, 1035-1043
| Abstract »
| PDF »
- Stimulation of transcription by an Ultrabithorax protein in vitro..
- F B Johnson and M A Krasnow (1990)
Genes & Dev.
4, 1044-1052
| Abstract »
| PDF »
- Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors..
- D M Simmons, J W Voss, H A Ingraham, J M Holloway, R S Broide, M G Rosenfeld, and L W Swanson (1990)
Genes & Dev.
4, 695-711
| Abstract »
| PDF »
- A two-base change in a POU factor-binding site switches pituitary-specific to lymphoid-specific gene expression..
- H P Elsholtz, V R Albert, M N Treacy, and M G Rosenfeld (1990)
Genes & Dev.
4, 43-51
| Abstract »
| PDF »
- A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally..
- H J Mangalam, V R Albert, H A Ingraham, M Kapiloff, L Wilson, C Nelson, H Elsholtz, and M G Rosenfeld (1989)
Genes & Dev.
3, 946-958
| Abstract »
| PDF »
- Cell-specific expression of the prolactin gene in transgenic mice is controlled by synergistic interactions between promoter and enhancer elements..
- E B Crenshaw, K Kalla, D M Simmons, L W Swanson, and M G Rosenfeld (1989)
Genes & Dev.
3, 959-972
| Abstract »
| PDF »
- Purification of growth hormone-specific transcription factor GHF-1 containing homeobox.
- J. Castrillo, M Bodner, and M Karin (1989)
Science
243, 814-817
| Abstract »
| PDF »
- The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products..
- W Herr, R A Sturm, R G Clerc, L M Corcoran, D Baltimore, P A Sharp, H A Ingraham, M G Rosenfeld, M Finney, and G Ruvkun (1988)
Genes & Dev.
2, 1513-1516
| PDF »
- The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains..
- R G Clerc, L M Corcoran, J H LeBowitz, D Baltimore, and P A Sharp (1988)
Genes & Dev.
2, 1570-1581
| Abstract »
| PDF »
- The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain..
- R A Sturm, G Das, and W Herr (1988)
Genes & Dev.
2, 1582-1599
| Abstract »
| PDF »
- Two mechanisms for the extinction of gene expression in hybrid cells.
- P Tripputi, S. Guerin, and D. Moore (1988)
Science
241, 1205-1207
| Abstract »
| PDF »
- Response and Binding Elements for Ligand-dependent Positive Transcription Factors Integrate Positive and Negative Regulation of Gene Expression.
- M.G. Rosenfeld, C.K. Glass, S. Adler, E.B. Crenshaw III, X. He, S.A. Lira, H.P. Elsholtz, H.J. Mangalam, J.M. Holloway, C. Nelson, et al. (1988)
Cold Spring Harb Symp Quant Biol
53, 545-556
| Abstract »
| PDF »
- Differentiation of Lactotrope Precursor GHFT Cells in Response to Fibroblast Growth Factor-2.
- J. Lopez-Fernandez, D. Palacios, A. I. Castillo, R. M. Tolon, A. Aranda, and M. Karin (2000)
J. Biol. Chem.
275, 21653-21660
| Abstract »
| Full Text »
| PDF »
- Elk-1, C/EBPalpha , and Pit-1 Confer an Insulin-responsive Phenotype on Prolactin Promoter Expression in Chinese Hamster Ovary Cells and Define the Factors Required for Insulin-increased Transcription.
- K. K. Jacob and F. M. Stanley (2001)
J. Biol. Chem.
276, 24931-24936
| Abstract »
| Full Text »
| PDF »
|
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