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Science 26 February 1988:
Vol. 239. no. 4843, pp. 1029 - 1033
DOI: 10.1126/science.2964082
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Articles

Science, Vol 239, Issue 4843, 1029-1033
Copyright © 1988 by American Association for the Advancement of Science

articles

Atrial natriuretic factor-SV40 T antigen transgenes produce tumors and cardiac arrhythmias in mice

LJ Field

Cold Spring Harbor Laboratory, NY 11724.

Transgenic mice that carry fusions between the transcriptional regulatory sequences of atrial natriuretic factor (a hormone intimately involved in the regulation of blood pressure) and those encoding SV40 T antigen (an oncoprotein) were generated. Although both atria express the fusion gene, the pathological response to T antigen is asymmetrical. The right atrium undergoes a several hundredfold increase in mass while the left atrium remains relatively normal in size. Hyperplasia is accompanied by a progressive increase in both the frequency and severity of abnormalities in the atrial conduction system, which ultimately result in death.


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