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Science 26 February 1988:
Vol. 239. no. 4843, pp. 1026 - 1029
DOI: 10.1126/science.2894075
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Articles

Science, Vol 239, Issue 4843, 1026-1029
Copyright © 1988 by American Association for the Advancement of Science

articles

A newly characterized HLA DQ beta allele associated with pemphigus vulgaris

AA Sinha, C Brautbar, F Szafer, A Friedmann, E Tzfoni, JA Todd, L Steinman, and HO McDevitt

Department of Medical Microbiology, Stanford University, CA 94305.

The inheritance of particular alleles of major histocompatibility complex class II genes increases the risk for various human autoimmune diseases; however, only a small percentage of individuals having an allele associated with susceptibility develop disease. The identification of allelic variants more precisely correlated with disease susceptibility would greatly facilitate clinical screening and diagnosis. Oligonucleotide-primed gene amplification in vitro was used to determine the nucleotide sequence of a class II variant found almost exclusively in patients with the autoimmune skin disease pemphigus vulgaris. In addition to clinical implications, the disease-restricted distribution of this variant should provide insight into the molecular mechanisms underlying associations between diseases and HLA-class II genes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
T Cell Recognition of Desmoglein 3 Peptides in Patients with Pemphigus Vulgaris and Healthy Individuals.
C. M. Veldman, K. L. Gebhard, W. Uter, R. Wassmuth, J. Grotzinger, E. Schultz, and M. Hertl (2004)
J. Immunol. 172, 3883-3892
   Abstract »    Full Text »    PDF »
Dichotomy of Autoreactive Th1 and Th2 Cell Responses to Desmoglein 3 in Patients with Pemphigus Vulgaris (PV) and Healthy Carriers of PV-Associated HLA Class II Alleles.
C. Veldman, A. Stauber, R. Wassmuth, W. Uter, G. Schuler, and M. Hertl (2003)
J. Immunol. 170, 635-642
   Abstract »    Full Text »    PDF »
PEMPHIGUS VULGARIS: UPDATE ON ETIOPATHOGENESIS, ORAL MANIFESTATIONS, AND MANAGEMENT.
C. Scully and S. J. Challacombe (2002)
Critical Reviews in Oral Biology & Medicine 13, 397-408
   Abstract »    Full Text »    PDF »
Research Advances in Pemphigus.
G. J. Anhalt and L. A. Diaz (2001)
JAMA 285, 652-654
   Abstract »    Full Text »    PDF »
PCR-based HLA class II typing..
U Gyllensten and M Allen (1991)
Genome Res. 1, 91-98
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Pemphigus: An Alternative Approach to Treatment.
V. B. Morhenn (1990)
Arch Dermatol 126, 1238
   Abstract »    PDF »
Autoimmune diseases: the failure of self tolerance.
A. Sinha, M. Lopez, and H. McDevitt (1990)
Science 248, 1380-1388
   Abstract »    PDF »
Evolution, Function, and Utilization of Major Histocompatibility Complex Polymorphism in Autoimmune Disease.
H.O. McDevitt, D.C. Wraith, D.E. Smilek, A.S. Lundberg, and L. Steinman (1989)
Cold Spring Harb Symp Quant Biol 54, 853-857
   Abstract »    PDF »
Autoimmune Disease and T-cell Immunologic Recognition.
L. Hood, V. Kumar, G. Osman, S.S. Beall, C. Gomez, W. Funkhouser, D.H. Kono, D. Nickerson, D.M. Zaller, and J.L. Urban (1989)
Cold Spring Harb Symp Quant Biol 54, 859-874
   Abstract »    PDF »
DNA diagnostics--molecular techniques and automation.
U Landegren, R Kaiser, C. Caskey, and L Hood (1988)
Science 242, 229-237
   Abstract »    PDF »
A molecular basis for MHC class II--associated autoimmunity.
J. Todd, H Acha-Orbea, J. Bell, N Chao, Z Fronek, C. Jacob, M McDermott, A. Sinha, L Timmerman, L Steinman, et al. (1988)
Science 240, 1003-1009
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