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Science 26 February 1988:
Vol. 239. no. 4843, pp. 1018 - 1021
DOI: 10.1126/science.3278377
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Articles

Science, Vol 239, Issue 4843, 1018-1021
Copyright © 1988 by American Association for the Advancement of Science

articles

Molecular cloning of the zeta chain of the T cell antigen receptor

AM Weissman, M Baniyash, D Hou, LE Samelson, WH Burgess, and RD Klausner

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892.

The T cell antigen receptor is a multi-subunit receptor complex present on the surface of all mature and many developing T cells. It consists of clonotypic heterodimers noncovalently linked to five invariant chains that are encoded by four genes and referred to as the CD3 complex. The CD3 gamma, delta, and epsilon chains have been molecularly characterized. In this report the molecular cloning of a complementary DNA encoding the zeta chain of the murine T cell antigen receptor is described. The predicted protein sequence of the zeta chain suggests a structure distinct from those of any of the previously described receptor subunits.


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