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Science 26 February 1988:
Vol. 239. no. 4843, pp. 1013 - 1015
DOI: 10.1126/science.3344420
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Articles

Science, Vol 239, Issue 4843, 1013-1015
Copyright © 1988 by American Association for the Advancement of Science

articles

Scanning tunneling microscopy of freeze-fracture replicas of biomembranes

JA Zasadzinski, J Schneir, J Gurley, V Elings, and PK Hansma

Department of Chemical and Nuclear Engineering, University of California, Santa Barbara 93106.

The high resolution of the scanning tunneling microscope (STM) makes it a potentially important tool for the study of biomaterials. Biological materials can be imaged with the STM by a procedure in which fluid, nonconductive biomaterials are replaced by rigid and highly conductive freeze-fracture replicas. The three-dimensional contours of the ripple phase of dimyristoylphosphatidylcholine bilayers were imaged with unprecedented resolution with commercial STMs and standard freeze-fracture techniques. Details of the ripple amplitude, asymmetry, and configuration unobtainable by electron microscopy or x-ray diffraction can be observed relatively easily with the STM.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Observations of the Liquid-Crystal Analog of the Abrikosov Phase.
K. J. Ihn, J. A. N. Zasadzinski, R. Pindak, A. J. Slaney, and J. Goodby (1992)
Science 258, 275-278
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Molecular structure of DNA by scanning tunneling microscopy.
A Cricenti, S Selci, A. Felici, R Generosi, E Gori, W Djaczenko, and G Chiarotti (1989)
Science 245, 1226-1227
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Scanning tunneling microscopy of uncoated recA-DNA complexes.
M Amrein, R Durr, A Stasiak, H Gross, and G Travaglini (1989)
Science 243, 1708-1711
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Direct observation of native DNA structures with the scanning tunneling microscope.
T. Beebe Jr, T. Wilson, D. Ogletree, J. Katz, R Balhorn, M. Salmeron, and W. Siekhaus (1989)
Science 243, 370-372
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X-ray Scattering Studies of Aligned, Stacked Surfactant Membranes.
E. B. Sirota, G. S. Smith, C. R. Safinya, R. J. Plano, and N. A. Clark (1988)
Science 242, 1406-1409
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Scanning tunneling microscopy and atomic force microscopy: application to biology and technology.
P. Hansma, V. Elings, O Marti, and C. Bracker (1988)
Science 242, 209-216
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